https://test.maltsci.com/en/paper/Recent content in Curated Papers on MaltSci 麦伴科研Hugo -- 0.154.5enhttps://test.maltsci.com/en/paper/pmid/34914339/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34914339/This study investigates the impact of adjuvant chemotherapy on invasive disease-free survival in premenopausal and postmenopausal women with hormone-receptor-positive, HER2-negative breast cancer andhttps://test.maltsci.com/en/paper/pmid/822353/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/822353/This study identifies a conserved sequence (A-A-U-A-A-A) located approximately 20 residues upstream of the 3''-terminal poly (A) sequence in various purified mRNAs, including alpha- and beta-globulin fhttps://test.maltsci.com/en/paper/pmid/30452086/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30452086/This research highlights the significant impact of cancer screening on reducing incidence and mortality for various cancers since the mid-20th century, but it also identifies shortcomings in access anhttps://test.maltsci.com/en/paper/pmid/34016775/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34016775/This study explores the enhancement of prosthetic arm control for individuals with tetraplegia through a bidirectional brain-computer interface that provides tactile feedback via intracortical microsthttps://test.maltsci.com/en/paper/pmid/32459504/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32459504/This review discusses the evolution of organoid technology, which provides advanced three-dimensional in vitro models that mimic the complexity and functionality of human tissues, overcoming the limithttps://test.maltsci.com/en/paper/pmid/24686414/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24686414/This article outlines the evolution of synthetic biology from its origins over fifty years ago to its current status as a transformative field in biotechnology and medicine, driven by advancements inhttps://test.maltsci.com/en/paper/pmid/36769023/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36769023/This review highlights the transformative role of mRNA vaccines, particularly during the COVID-19 pandemic, showcasing their advantages in potency, safety, and rapid development facilitated by advancehttps://test.maltsci.com/en/paper/pmid/16838020/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/16838020/This study demonstrates a significantly improved brain-computer interface (BCI) using electrode arrays implanted in the monkey dorsal premotor cortex, achieving a key selection speed of up to 6.5 bitshttps://test.maltsci.com/en/paper/pmid/33078077/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33078077/This review highlights the critical role of materials science in advancing antiviral research during the SARS-CoV-2 pandemic, focusing on innovations in imaging systems, microfluidic devices, and viruhttps://test.maltsci.com/en/paper/pmid/31114756/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31114756/This review highlights the challenges posed by the tumor microenvironment (TME) on the efficacy of CAR T cell therapy due to the high metabolic demands of tumor cells that compete for essential nutriehttps://test.maltsci.com/en/paper/pmid/21364738/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21364738/This study introduces a hierarchical modular cloning (MoClo) system that enables efficient assembly of complex eukaryotic multigene constructs using type IIS restriction enzymes, significantly advancihttps://test.maltsci.com/en/paper/pmid/25917172/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25917172/This study presents a novel CRISPR/Cas9 vector system optimized for efficient multiplex genome editing in both monocot and dicot plants, achieving high mutation rates in rice and Arabidopsis. The apprhttps://test.maltsci.com/en/paper/pmid/32651371/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32651371/This study introduces a CRISPR-edited Leishmania major strain (LmCen-/-) as a second-generation vaccine for leishmaniasis, addressing the safety concerns associated with traditional leishmanization byhttps://test.maltsci.com/en/paper/pmid/30405621/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30405621/This study evaluates four widely used single-cell RNA sequencing (scRNA-seq) platforms, highlighting their respective advantages and limitations to guide users in selecting the most appropriate protochttps://test.maltsci.com/en/paper/pmid/38459338/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38459338/This study identifies TRAF2- and NCK-interacting kinase (TNIK) as a novel anti-fibrotic target for idiopathic pulmonary fibrosis (IPF) and develops INS018_055, a small-molecule TNIK inhibitor, using ahttps://test.maltsci.com/en/paper/pmid/33107982/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33107982/This study systematically reviewed oncology guidelines from 2009 to 2019 to identify rehabilitation-specific recommendations, highlighting that while 37 out of 69 guidelines endorsed referrals to rehahttps://test.maltsci.com/en/paper/pmid/32795413/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32795413/This study presents ARCoV, a lipid nanoparticle-encapsulated mRNA vaccine encoding the receptor binding domain of SARS-CoV-2, which demonstrates strong neutralizing antibody responses and effective prhttps://test.maltsci.com/en/paper/pmid/32348718/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32348718/This study investigates the impact of pre-existing immunity to the SaCas9 protein on the efficacy of AAV-mediated CRISPR-Cas9 genome editing in the liver of mice. While efficient genome editing was achttps://test.maltsci.com/en/paper/pmid/34504303/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34504303/This review highlights the urgent need for innovative approaches in antibiotic discovery due to the rising threat of antimicrobial resistance, emphasizing the role of artificial intelligence in enhanchttps://test.maltsci.com/en/paper/pmid/22439926/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22439926/This research highlights the critical role of stromal cells in supporting tumor development and progression alongside mutated cancer cells, emphasizing the complex interactions that facilitate the forhttps://test.maltsci.com/en/paper/pmid/23852650/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23852650/This study demonstrates that brain-computer interface (BCI)-controlled adaptive deep brain stimulation (aDBS) significantly improves motor function in patients with advanced Parkinson''s disease comparhttps://test.maltsci.com/en/paper/pmid/9717241/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/9717241/This study presents a novel set of plasmids designed for one-step PCR-mediated gene deletion and modification in Saccharomyces cerevisiae, enabling rapid and versatile gene manipulations without the nhttps://test.maltsci.com/en/paper/pmid/33321139/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33321139/This commentary highlights the challenges of formulation and stability of mRNA vaccines, particularly in the context of the COVID-19 pandemic, and emphasizes the need for systematic approaches to idenhttps://test.maltsci.com/en/paper/pmid/26000845/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26000845/Single-cell sequencing (SCS) has revolutionized the study of rare cells and complex populations across various biological fields, such as microbiology, neurobiology, and cancer research, over the pasthttps://test.maltsci.com/en/paper/pmid/38915099/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38915099/This review highlights the challenges and progress of chimeric antigen receptor T (CAR-T) cell therapy for aggressive T-cell malignancies, noting that while advances have been made in treating B-cellhttps://test.maltsci.com/en/paper/pmid/35322018/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35322018/This review highlights the urgent need for effective COVID-19 vaccination in light of the pandemic''s global impact, characterized by over 399 million cases and 5.7 million deaths. It focuses on the adhttps://test.maltsci.com/en/paper/pmid/30972078/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30972078/This review discusses the significant advancements in RNA-based technologies, particularly mRNA vaccines, which have demonstrated safety and durability in eliciting immune responses in both preclinicahttps://test.maltsci.com/en/paper/pmid/40971231/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40971231/Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer often diagnosed at advanced stages due to non-specific early symptoms and therapeutic resistance, with rising incidence linked tohttps://test.maltsci.com/en/paper/pmid/36260350/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36260350/Intrahepatic cholangiocarcinoma (ICC) is a highly fatal liver malignancy with limited curative options, as only 20%-30% of patients are surgical candidates, and systemic therapies yield approximatelyhttps://test.maltsci.com/en/paper/pmid/34691052/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34691052/This paper reviews the advancements and challenges of chimeric antigen receptor T (CAR-T) cell therapy, particularly highlighting the potential of universal CAR-T (UCAR-T) cell therapy to address issuhttps://test.maltsci.com/en/paper/pmid/31320117/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31320117/This paper explores the integration of artificial intelligence (AI) with novel experimental technologies to enhance the drug discovery process, which is currently hindered by high costs and lengthy tihttps://test.maltsci.com/en/paper/pmid/35058619/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35058619/This research paper highlights the transformative potential of artificial intelligence (AI) in medicine, emphasizing significant advancements in medical image analysis and the bridging of research withttps://test.maltsci.com/en/paper/pmid/36794205/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36794205/This study highlights the innovative application of AlphaFold in an AI-driven drug discovery pipeline, successfully identifying a novel small molecule, ISM042-2-048, targeting cyclin-dependent kinasehttps://test.maltsci.com/en/paper/pmid/33986301/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33986301/This Primer discusses Alzheimer''s disease (AD) as a neurodegenerative disorder characterized by β-amyloid plaques and tau tangles, highlighting its complexity due to interactions with other conditionshttps://test.maltsci.com/en/paper/pmid/12399581/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/12399581/This study investigates the early clinical phase of Alzheimer''s disease, which primarily manifests as a pure memory impairment linked to subtle changes in hippocampal synaptic efficacy before noticeabhttps://test.maltsci.com/en/paper/pmid/16876668/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/16876668/This seminar reviews the complexities of Alzheimer''s disease, highlighting the distinction between rare familial forms caused by specific genetic mutations and the more common sporadic cases, which lahttps://test.maltsci.com/en/paper/pmid/21371747/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21371747/This seminar reviews recent findings on Alzheimer''s disease, highlighting its significant public health impact due to the estimated 24 million affected individuals globally and the urgent need for imphttps://test.maltsci.com/en/paper/pmid/21576255/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21576255/This paper reviews the significant advances in understanding the molecular mechanisms of neurodegenerative diseases, particularly Alzheimer''s disease, over the past thirty years, highlighting the rolehttps://test.maltsci.com/en/paper/pmid/26921134/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26921134/This research highlights the evolving understanding of Alzheimer''s disease, emphasizing that while traditional biomarkers like amyloid and tau remain critical, the interaction of various age-related fhttps://test.maltsci.com/en/paper/pmid/27188934/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27188934/Alzheimer''s disease, prevalent in 10-30% of individuals over 65, has a long preclinical phase and primarily affects the elderly with sporadic forms linked to amyloid-β clearance failure. While genetichttps://test.maltsci.com/en/paper/pmid/28872215/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28872215/This review examines the epidemiology, genetics, and pathogenesis of Alzheimer''s disease, highlighting the significance of its protracted preclinical phase in informing new therapeutic strategies. Thehttps://test.maltsci.com/en/paper/pmid/31753135/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31753135/Alzheimer''s disease (AD) dementia is characterized by cognitive decline and specific neuropathological changes, with modern criteria enabling the recognition of preclinical stages through biomarkers.https://test.maltsci.com/en/paper/pmid/33667416/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33667416/This seminar reviews significant advancements in Alzheimer''s disease research, highlighting that by 2050, dementia prevalence is expected to triple globally, with genetic factors playing a crucial rolhttps://test.maltsci.com/en/paper/pmid/34687637/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34687637/Adults with Down syndrome are at a significantly increased risk of early-onset dementia, a leading cause of death in this group, yet diagnosing dementia is challenging due to overlapping symptoms withhttps://test.maltsci.com/en/paper/pmid/37729908/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37729908/Recent trials of Aβ-immunotherapy have demonstrated that clearing aggregated Aβ from the brains of symptomatic Alzheimer''s patients can modestly slow disease progression, underscoring the need for imphttps://test.maltsci.com/en/paper/pmid/11274343/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/11274343/This study highlights the significant advancements in understanding Alzheimer''s disease (AD) through molecular and cell biology, particularly the genotype-phenotype relationships linked to familial fohttps://test.maltsci.com/en/paper/pmid/39141853/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/39141853/This study demonstrates that an intracortical speech neuroprosthesis can effectively restore conversational communication in a 45-year-old man with ALS, achieving up to 99.6% accuracy after minimal trhttps://test.maltsci.com/en/paper/pmid/17399797/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/17399797/This study investigates the feasibility of an auditory brain-computer interface (BCI) for individuals with severely impaired vision, comparing it to a visual BCI. While initial performance was betterhttps://test.maltsci.com/en/paper/pmid/19556461/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/19556461/This study identifies the Mmm1/Mdm10/Mdm12/Mdm34 complex as a crucial molecular tether between mitochondria and the endoplasmic reticulum (ER), which is essential for facilitating interorganelle commuhttps://test.maltsci.com/en/paper/pmid/37172564/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37172564/This study introduces an innovative in vivo xenotransplantation approach to model human microglia (hMGs) within a vascularized immunocompetent human brain organoid (iHBO), revealing that hMGs adopt huhttps://test.maltsci.com/en/paper/pmid/31959345/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31959345/This study updates the EORTC QLQ-BR23 questionnaire for assessing quality of life in breast cancer patients, reflecting changes in treatment since its original development in 1996. The revised EORTC Qhttps://test.maltsci.com/en/paper/pmid/17475511/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/17475511/This study explores the potential of magnetoencephalography (MEG)-based brain-computer interfaces (BCIs) for communication by analyzing voluntary amplitude modulation of sensorimotor rhythms, revealinhttps://test.maltsci.com/en/paper/pmid/32663912/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32663912/This phase 1 trial evaluated the safety and immunogenicity of the mRNA-1273 vaccine in 45 healthy adults, revealing that higher doses elicited significantly stronger antibody responses after two vaccihttps://test.maltsci.com/en/paper/pmid/24705333/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24705333/The study presents cancer personalized profiling by deep sequencing (CAPP-Seq), an economical and ultrasensitive method for quantifying circulating tumor DNA (ctDNA), which demonstrated over 95% mutathttps://test.maltsci.com/en/paper/pmid/32841388/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32841388/This review highlights the transformative impact of immunotherapy, particularly checkpoint inhibitors like nivolumab and pembrolizumab, in treating lung cancer and head and neck squamous cell carcinomhttps://test.maltsci.com/en/paper/pmid/23484797/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23484797/This study investigates the effectiveness of circulating tumor DNA (ctDNA) as a biomarker for monitoring treatment response in metastatic breast cancer, comparing it with traditional markers like CA 1https://test.maltsci.com/en/paper/pmid/41101309/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41101309/This study investigates the efficacy of anti-B cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in five patients with progressive multiple sclerosis (PMS), showing promihttps://test.maltsci.com/en/paper/pmid/34183822/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34183822/This review highlights the significance of host defence peptides (HDPs) in innate immunity, emphasizing their multifunctional roles, particularly their antibiofilm properties alongside traditional anthttps://test.maltsci.com/en/paper/pmid/34546590/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34546590/This review addresses the critical issue of antibiotic resistance in cancer patients, particularly concerning ESKAPE pathogens, which poses significant health and financial challenges in this vulnerabhttps://test.maltsci.com/en/paper/pmid/34108022/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34108022/This review discusses the transformative impact of single-cell sequencing technologies on cancer research, highlighting their ability to provide detailed insights into tumor heterogeneity, malignant ahttps://test.maltsci.com/en/paper/pmid/37169742/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37169742/This review highlights the advancements in synthetic biology, which has evolved to create engineered biocircuits and enhance microbial production of pharmaceuticals, as well as develop novel therapeuthttps://test.maltsci.com/en/paper/pmid/40972630/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40972630/This research discusses the pressing challenge of antimicrobial resistance (AMR) and the UN General Assembly''s targets for addressing its impact on health systems, emphasizing the potential role of arhttps://test.maltsci.com/en/paper/pmid/37697042/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37697042/This research highlights the synergy between advancements in computational omics technologies and artificial intelligence in drug discovery, emphasizing their potential to uncover new natural producthttps://test.maltsci.com/en/paper/pmid/30720861/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30720861/This study reviews the application of artificial intelligence (AI) in the medical imaging of cancer, highlighting its potential to enhance the qualitative interpretation of images, improve tumor monithttps://test.maltsci.com/en/paper/pmid/33811123/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33811123/This research highlights the transformative impact of artificial intelligence (AI) on cancer research and personalized clinical care, driven by the availability of high-dimensional datasets and advanchttps://test.maltsci.com/en/paper/pmid/35538061/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35538061/This review highlights the use of artificial intelligence in identifying novel anticancer targets and discovering new drugs through biological networks that reflect cellular interactions related to cahttps://test.maltsci.com/en/paper/pmid/40662528/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40662528/This paper reviews the potential of artificial intelligence (AI) in enhancing cardiovascular pharmacotherapy by optimizing drug selection and personalizing treatment, thereby improving patient outcomehttps://test.maltsci.com/en/paper/pmid/31399699/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31399699/This study highlights the growing need for predictive assays in precision oncology, emphasizing the complexity of cancer''s signaling networks that hinder the development of effective biomarkers. It evhttps://test.maltsci.com/en/paper/pmid/30472429/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30472429/This review highlights the potential of artificial intelligence (AI) to transform drug development amidst rising R&D costs and inefficiencies faced by the pharmaceutical industry. It discusses the cauhttps://test.maltsci.com/en/paper/pmid/33099022/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33099022/This paper explores the transformative impact of artificial intelligence on drug discovery and development within the pharmaceutical industry, highlighting various integration areas, employed tools, ahttps://test.maltsci.com/en/paper/pmid/33779453/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33779453/This paper reviews the current status of artificial intelligence, particularly deep learning, in chemoinformatics and its applications in drug discovery, highlighting advancements in modeling techniquhttps://test.maltsci.com/en/paper/pmid/33346134/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33346134/This article highlights the limited advances of artificial intelligence in drug discovery compared to its impact in other fields, emphasizing that improvements in clinical success rates are more crucihttps://test.maltsci.com/en/paper/pmid/29507784/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29507784/This paper explores the transformative role of artificial intelligence (AI) in healthcare, highlighting its applications across various data types and major disease areas, particularly in stroke managhttps://test.maltsci.com/en/paper/pmid/31015651/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31015651/This review article discusses the transformative impact of artificial intelligence (AI) on medical practice, highlighting recent advancements in AI technologies and their applications in biomedicine.https://test.maltsci.com/en/paper/pmid/37514102/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37514102/This review discusses the transformative potential of artificial intelligence (AI) in drug discovery and development, emphasizing its ability to analyze biological data for identifying disease targetshttps://test.maltsci.com/en/paper/pmid/29777175/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29777175/This Opinion article highlights the significant advancements AI algorithms, especially deep learning, have made in medical image analysis, particularly in radiology, where they offer superior patternhttps://test.maltsci.com/en/paper/pmid/30592986/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30592986/This study addresses the urgent need for standardized definitions and grading systems for cytokine release syndrome (CRS) and neurotoxicity associated with chimeric antigen receptor (CAR) T cell therahttps://test.maltsci.com/en/paper/pmid/34417579/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34417579/This review examines the advancements in therapeutic strategies for atopic dermatitis (AD), a challenging chronic inflammatory skin condition, highlighting recent discoveries of novel drug candidateshttps://test.maltsci.com/en/paper/pmid/35697835/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35697835/This study introduces an automated multi-scale 3D imaging platform that enhances the characterization of high-density organoid cultures using live 3D light-sheet imaging, achieving a throughput of 300https://test.maltsci.com/en/paper/pmid/21211070/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21211070/This review explores the clinical and biological aspects of autosomal-dominant Alzheimer''s disease, emphasizing its similarities and differences with sporadic cases, while also discussing recent develhttps://test.maltsci.com/en/paper/pmid/29226797/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29226797/In a phase 2 trial involving 111 patients with refractory large B-cell lymphoma, axicabtagene ciloleucel (axi-cel) demonstrated an 82% objective response rate and a 54% complete response rate, with 42https://test.maltsci.com/en/paper/pmid/35044794/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35044794/This study explores the diverse roles of B lymphocytes within the tumor microenvironment (TME), highlighting their significance in antitumor immunity alongside T lymphocytes, which have been more extehttps://test.maltsci.com/en/paper/pmid/31992873/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31992873/This review explores the dual role of bacterial polymers, which serve as key virulence factors in pathogenic bacteria while offering potential for food and biomaterial applications when produced by nohttps://test.maltsci.com/en/paper/pmid/38962719/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38962719/This paper reviews the potential of engineering bacteria as therapeutic agents, emphasizing their dual role as effective treatments and potential sources of toxicity due to their immunostimulatory nathttps://test.maltsci.com/en/paper/pmid/35672571/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35672571/Chimeric antigen receptor T-cell (CAR-T) therapy has shown promising results in treating various hematologic malignancies by harnessing and engineering a patient''s own T cells to target cancer cells.https://test.maltsci.com/en/paper/pmid/26107944/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26107944/This study introduces BASiCS, a Bayesian hierarchical model designed to address the technical noise inherent in single-cell mRNA sequencing, allowing for improved identification of biologically variabhttps://test.maltsci.com/en/paper/pmid/23368723/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23368723/This study addresses the challenge of error correction in single-cell sequencing, where traditional tools fall short due to non-uniform coverage. The authors introduce BAYESHAMMER, a novel algorithm lhttps://test.maltsci.com/en/paper/pmid/15188875/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/15188875/This paper introduces BCI2000, a versatile brain-computer interface (BCI) research platform designed to support systematic evaluations and comparisons across various brain signals, processing methods,https://test.maltsci.com/en/paper/pmid/33908526/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33908526/This review highlights the recent advancements in understanding the biosynthetic pathways of psychoactive natural products, including hallucinogens, stimulants, cannabinoids, and opioids, by leveraginhttps://test.maltsci.com/en/paper/pmid/33326126/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33326126/This research highlights the transformative impact of advancements in cancer screening, therapies, and biological understanding on personalized cancer care, while emphasizing the need for improved coohttps://test.maltsci.com/en/paper/pmid/33626250/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33626250/This study evaluates the effectiveness of the BNT162b2 mRNA vaccine against COVID-19 using data from Israel''s largest healthcare organization, revealing that the vaccine demonstrated significant effechttps://test.maltsci.com/en/paper/pmid/34427324/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34427324/This study analyzes population-based data to assess the burden of brain and CNS tumors in the U.S., revealing a decline in malignant tumor incidence rates overall, yet an increase among children and ahttps://test.maltsci.com/en/paper/pmid/22438708/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22438708/This review paper explores the advancements and methodologies in brain-computer interfaces (BCIs), which enable communication for severely disabled individuals by using cerebral activity to control exhttps://test.maltsci.com/en/paper/pmid/29601538/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29601538/This review consolidates and categorizes various Brain-Computer Interface (BCI) spellers developed since 2010, highlighting their underlying paradigms such as P300, SSVEP, and motor imagery, and aimshttps://test.maltsci.com/en/paper/pmid/12048038/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/12048038/This research explores the development of brain-computer interfaces (BCIs) as a means for individuals with severe neuromuscular disorders to communicate and control devices, leveraging various electrohttps://test.maltsci.com/en/paper/pmid/27539560/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27539560/This review examines the evolution and current technologies of brain-computer interfaces (BCIs), focusing on their applications for communication and motor rehabilitation in severely disabled patientshttps://test.maltsci.com/en/paper/pmid/40988938/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40988938/This paper reviews the development of brain-computer interfaces (BCIs) aimed at personalizing deep brain stimulation therapy for treatment-resistant neuropsychiatric disorders, such as major depressiohttps://test.maltsci.com/en/paper/pmid/22325364/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22325364/This paper discusses the development and potential of brain-computer interfaces (BCIs) as a transformative technology for individuals with neuromuscular disorders, enabling control of devices that canhttps://test.maltsci.com/en/paper/pmid/18835541/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/18835541/Recent advancements in brain signal analysis and non-invasive EEG-based brain-computer interface (BCI) technologies have enabled individuals with severe motor disabilities to communicate and control thttps://test.maltsci.com/en/paper/pmid/31504126/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31504126/This study evaluates the Breast Cancer Index (BCI) as a predictive biomarker for the benefit of extended endocrine therapy in early-stage hormone receptor-positive breast cancer patients, finding thathttps://test.maltsci.com/en/paper/pmid/36512303/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36512303/As the population ages, patients with cancer are increasingly affected by dementia, leading to significant health disparities that complicate cancer care and outcomes. The research highlights that peohttps://test.maltsci.com/en/paper/pmid/36512337/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36512337/This review discusses the role of epigenetic modifications, particularly DNA methylation and histone marks, in cancer development and progression, emphasizing their potential as diagnostic and therapehttps://test.maltsci.com/en/paper/pmid/33433946/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33433946/The American Cancer Society projects 1,898,160 new cancer cases and 608,570 deaths in the U.S. for 2021, with a notable 31% decline in cancer mortality since its peak in 1991, largely due to reduced shttps://test.maltsci.com/en/paper/pmid/36633525/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36633525/The American Cancer Society projects 1,958,310 new cancer cases and 609,820 deaths in the U.S. for 2023, highlighting an increase in prostate cancer incidence and contrasting trends in lung cancer bethttps://test.maltsci.com/en/paper/pmid/29567707/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29567707/This review highlights the rapid advancement of adoptive T cell transfer (ACT) in transfusion medicine, particularly the commercialization of chimeric antigen receptor (CAR) T cells for leukemia and lhttps://test.maltsci.com/en/paper/pmid/30459759/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30459759/This review examines the potential of chimeric antigen receptor (CAR) T cell therapy as a promising treatment for high-risk neuroblastoma, where current therapies yield only a 50% five-year survival rhttps://test.maltsci.com/en/paper/pmid/38438559/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38438559/This paper discusses the transformative impact of CAR T-cell therapy in treating multiple myeloma (MM), highlighting its effectiveness compared to traditional treatments and recent FDA approvals. It ehttps://test.maltsci.com/en/paper/pmid/37495877/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37495877/This review explores the expanding potential of chimaeric antigen receptor (CAR) T therapy beyond oncology, highlighting its promising applications in treating autoimmune diseases, chronic infections,https://test.maltsci.com/en/paper/pmid/36423579/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36423579/Mackensen et al. demonstrate in their recent Nature Medicine paper that CAR T cell therapy, traditionally used for hematologic cancers, can be effectively applied to treat systemic lupus erythematosushttps://test.maltsci.com/en/paper/pmid/28346697/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28346697/CAR T-cell therapy, which genetically modifies a patient''s T cells to attack cancer cells, has shown success in treating hematological malignancies and is being explored for solid tumors like pancreathttps://test.maltsci.com/en/paper/pmid/31622496/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31622496/This paper discusses the advancements in chimeric antigen receptor (CAR) T-cell therapy, particularly the success of CD19-targeted therapies for hematological cancers like diffuse large B-cell lymphomhttps://test.maltsci.com/en/paper/pmid/33249873/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33249873/This narrative review highlights the increased infection risks faced by patients undergoing chimeric antigen receptor T-cell therapy (CAR-T), attributed to factors such as prior immunosuppression andhttps://test.maltsci.com/en/paper/pmid/33824268/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33824268/This review highlights the revolutionary potential of chimeric antigen receptor (CAR)-T cell therapy in treating cancers, particularly B cell leukemia and lymphoma, while addressing significant challehttps://test.maltsci.com/en/paper/pmid/34108020/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34108020/This study investigates the metabolic changes in plasma of relapsed or refractory multiple myeloma (MM) patients undergoing CAR T cell therapy, identifying glycerophosphocholine (GPC) and lysophosphathttps://test.maltsci.com/en/paper/pmid/40233718/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40233718/This review addresses the challenges faced by chimeric antigen receptor (CAR) T cell therapy in treating solid tumors, particularly due to antigenic heterogeneity and the immunosuppressive tumor microhttps://test.maltsci.com/en/paper/pmid/32910493/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32910493/This review highlights the heightened risk of severe COVID-19 complications in patients with both cardiovascular disease (CVD) and cancer, emphasizing the urgent need for a unified management approachhttps://test.maltsci.com/en/paper/pmid/35257157/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35257157/This review examines the cardiovascular risks associated with chimeric antigen receptor (CAR)-T cell therapy, which is a promising cancer treatment that induces targeted immune responses but can leadhttps://test.maltsci.com/en/paper/pmid/30158648/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30158648/This study investigates the effects of urban green spaces on mental health, revealing that increased access to parks and green areas significantly enhances residents'' well-being and reduces stress levhttps://test.maltsci.com/en/paper/pmid/39102518/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/39102518/The article presents the Computational Anatomy Toolbox (CAT), a comprehensive and user-friendly suite for brain morphometric analyses that caters to users of all expertise levels. By offering a full ahttps://test.maltsci.com/en/paper/pmid/27111235/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27111235/This study evaluated CD19-specific CAR-T cells manufactured from defined CD4+ and CD8+ T cell subsets in adults with B cell acute lymphoblastic leukemia, achieving a high remission rate of 93%. The fihttps://test.maltsci.com/en/paper/pmid/32958874/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32958874/This study explores the role of intestinal stem cells in tissue renewal and repair, highlighting how lineage plasticity and niche signals enable efficient regeneration of the intestinal epithelium. Thhttps://test.maltsci.com/en/paper/pmid/40104998/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40104998/This review highlights the potential of cell-free synthetic biology in producing natural products, addressing challenges in isolating these compounds from their native sources and discussing advanceshttps://test.maltsci.com/en/paper/pmid/29062958/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29062958/This review highlights the advancements in cell-free synthetic biology, which enables the engineering of biological systems without living cells, thus allowing for more straightforward, rapid, and flehttps://test.maltsci.com/en/paper/pmid/23995685/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23995685/This study presents a novel three-dimensional organoid culture system derived from human pluripotent stem cells, which successfully replicates various brain regions and their development, including thhttps://test.maltsci.com/en/paper/pmid/34499351/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34499351/Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women, particularly in low-income countries and among those living with HIV, who have a significantly heightenedhttps://test.maltsci.com/en/paper/pmid/32729638/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32729638/The American Cancer Society has updated its cervical cancer screening guidelines, recommending that individuals with a cervix begin screenings at age 25 with primary HPV testing every 5 years, emphasihttps://test.maltsci.com/en/paper/pmid/41316450/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41316450/This review examines the potential of chimeric antigen receptor (CAR) T-cell therapy for treating autoimmune diseases (ADs), building on its success in hematological malignancies, particularly B-cellhttps://test.maltsci.com/en/paper/pmid/30514386/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30514386/This review highlights the transformative impact of Chimeric Antigen Receptor (CAR) T cell therapies in treating hematologic malignancies, underscored by recent FDA approvals and ongoing developmentshttps://test.maltsci.com/en/paper/pmid/31752943/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31752943/This paper discusses the challenges in treating refractory multiple myeloma (MM) and highlights the promising efficacy of chimeric antigen receptor (CAR)-modified T cell therapy as a novel approach, nhttps://test.maltsci.com/en/paper/pmid/38831163/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38831163/This research highlights the potential of CAR T cell therapy, originally successful for B cell malignancies, to treat autoimmune diseases by targeting specific B cell proteins like CD19. It discusseshttps://test.maltsci.com/en/paper/pmid/26574053/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26574053/This review discusses the evolution of chimeric antigen receptor (CAR) T cell therapy from a theoretical concept to a practical treatment for cancer, highlighting significant advancements in molecularhttps://test.maltsci.com/en/paper/pmid/25317870/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25317870/This study demonstrates that chimeric antigen receptor-modified T-cell therapy targeting CD19 (CTL019) is highly effective in treating relapsed or refractory acute lymphoblastic leukemia (ALL), achievhttps://test.maltsci.com/en/paper/pmid/36130152/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36130152/This review highlights the significant barriers to patient access for chimeric antigen receptor T-cell (CAR-T) therapies, which are vital for treating heavily pretreated hematologic malignancies but hhttps://test.maltsci.com/en/paper/pmid/31936611/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31936611/This review examines the application of chimeric antigen receptor (CAR) T-cell therapy in colorectal cancer, highlighting its emergence as a promising immunotherapy following successful results in hemhttps://test.maltsci.com/en/paper/pmid/23527958/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23527958/This study investigates the efficacy of chimeric antigen receptor (CAR) T cells targeting CD19 in two children with relapsed and refractory pre-B-cell acute lymphoblastic leukemia (ALL), demonstratinghttps://test.maltsci.com/en/paper/pmid/21830940/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21830940/This study developed a lentiviral vector to create chimeric antigen receptor (CAR) T cells targeting CD19 for treating refractory chronic lymphocytic leukemia (CLL), resulting in over a 1000-fold expahttps://test.maltsci.com/en/paper/pmid/18670422/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/18670422/This study demonstrates that a highly sensitive method for quantifying circulating tumor DNA (ctDNA) in patients undergoing treatment for colorectal cancer can effectively monitor tumor dynamics, provhttps://test.maltsci.com/en/paper/pmid/35122035/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35122035/This review highlights the rapid advancements in circulating tumor DNA (ctDNA) analysis for cancer detection, characterization, and monitoring, emphasizing its growing role as a diagnostic tool supporhttps://test.maltsci.com/en/paper/pmid/29569666/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29569666/This paper comprehensively reviews the potential of circulating tumor DNA (ctDNA) as a noninvasive liquid biopsy for cancer diagnosis, prognosis, and monitoring treatment responses, highlighting recenhttps://test.maltsci.com/en/paper/pmid/25388429/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25388429/This review highlights the potential of cell-free circulating tumor DNA (ctDNA) as a noninvasive liquid biopsy for monitoring cancer, addressing the limitations of traditional tumor tissue genotypinghttps://test.maltsci.com/en/paper/pmid/33165928/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33165928/This review highlights the growing use of plasma circulating tumor DNA (ctDNA) genomic profiling assays in managing advanced solid tumors, emphasizing their potential to enhance treatment decision-makhttps://test.maltsci.com/en/paper/pmid/27223063/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27223063/This paper reviews the potential of circulating tumor DNA (ctDNA) as a revolutionary approach for cancer diagnosis and management, highlighting its advantages over traditional tissue biopsies, which ahttps://test.maltsci.com/en/paper/pmid/22784036/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22784036/This study investigated the sequence and timing of pathological changes in autosomal dominant Alzheimer''s disease, revealing that amyloid-beta levels decline 25 years before expected symptom onset, wihttps://test.maltsci.com/en/paper/pmid/26969689/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26969689/This review highlights the clinical potential of liquid biopsy through the analysis of circulating tumor cells (CTCs) and circulating cell-free tumor DNA (ctDNA) for cancer detection, prognosis predichttps://test.maltsci.com/en/paper/pmid/6610841/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/6610841/The research outlines the clinical criteria for diagnosing Alzheimer''s disease, emphasizing the importance of recognizing insidious onset and cognitive decline without early motor or sensory deficits,https://test.maltsci.com/en/paper/pmid/37329269/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37329269/This paper reviews the challenges in treating small cell lung cancer (SCLC), a disease closely linked to tobacco and characterized by rapid growth and high metastatic potential, with a focus on its gehttps://test.maltsci.com/en/paper/pmid/35472088/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35472088/Colorectal cancer (CRC) is a leading cause of cancer mortality, with a significant portion of patients presenting with metastatic disease, which poses challenges in management. This review highlightshttps://test.maltsci.com/en/paper/pmid/35969145/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35969145/This study reviews communication strategies used by healthcare clinicians to improve HPV vaccination rates, highlighting that strong and presumptive recommendations significantly enhance vaccine uptakhttps://test.maltsci.com/en/paper/pmid/32133645/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32133645/Colorectal cancer (CRC) remains a significant health concern in the U.S., with an estimated 147,950 diagnoses and 53,200 deaths in 2020, particularly affecting younger adults under 50, where incidencehttps://test.maltsci.com/en/paper/pmid/24264989/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24264989/This study investigates the role of gut microbiota in modulating inflammation within the tumor microenvironment and its impact on cancer therapy effectiveness. The findings reveal that disruption of mhttps://test.maltsci.com/en/paper/pmid/40377134/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40377134/Vulvar and vaginal cancers are rare malignancies predominantly affecting older women, with a significant association to HPV infections, and while surgical intervention is the primary treatment, limitehttps://test.maltsci.com/en/paper/pmid/30013197/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30013197/This study investigates the efficacy of pembrolizumab in metastatic gastric cancer (mGC), revealing that patients with microsatellite instability-high and Epstein-Barr virus-positive tumors exhibit rehttps://test.maltsci.com/en/paper/pmid/31294972/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31294972/This review explores the application of artificial intelligence, particularly deep learning, in drug discovery and design, highlighting various machine learning techniques and their roles in areas suchttps://test.maltsci.com/en/paper/pmid/36305841/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36305841/This review addresses the rising incidence of oropharyngeal cancer (OPC) linked to HPV infection and the challenges in optimizing deintensification strategies for treatment, as initial randomized triahttps://test.maltsci.com/en/paper/pmid/22138822/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22138822/This research introduces a novel method utilizing Cre recombinase-inducible retrovirus vectors to facilitate the conditional manipulation of gene expression in primary mouse organoid cultures, addresshttps://test.maltsci.com/en/paper/pmid/40993223/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40993223/This review highlights the complexity of heart development, emphasizing the interplay of tissue organization, cellular lineages, and molecular factors, while showcasing how advancements in imaging, gehttps://test.maltsci.com/en/paper/pmid/32478678/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32478678/This review discusses the potential of genome editing technologies, particularly CRISPR/Cas9, to correct mutations responsible for muscular dystrophies, such as Duchenne muscular dystrophy, which havehttps://test.maltsci.com/en/paper/pmid/32998157/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32998157/The BNT162b1 mRNA vaccine, targeting the receptor binding domain of the SARS-CoV-2 spike protein, demonstrated robust antibody and T cell responses in a phase I/II trial with healthy adults, yieldinghttps://test.maltsci.com/en/paper/pmid/35249272/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35249272/This study assessed the effectiveness of COVID-19 vaccines against symptomatic disease from the omicron and delta variants in England, revealing that primary immunization with ChAdOx1 nCoV-19 or BNT16https://test.maltsci.com/en/paper/pmid/32606465/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32606465/This study investigates the impact of climate change on agricultural productivity, revealing that rising temperatures and altered precipitation patterns significantly reduce crop yields in various reghttps://test.maltsci.com/en/paper/pmid/41775694/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41775694/The study investigates the impact of urban green spaces on mental health, revealing that increased access to parks and greenery significantly reduces stress and improves overall well-being among urbanhttps://test.maltsci.com/en/paper/pmid/31015699/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31015699/The study investigates the impact of urban green spaces on mental health, revealing that increased access to parks and nature significantly reduces stress and improves overall well-being in urban popuhttps://test.maltsci.com/en/paper/pmid/27882996/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27882996/This study investigates the impact of climate change on agricultural productivity, revealing that rising temperatures and extreme weather events significantly reduce crop yields in various regions. Thhttps://test.maltsci.com/en/paper/pmid/36797479/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36797479/This study investigates the impact of urban green spaces on residents'' mental well-being, highlighting a positive correlation between the availability of parks and reduced stress levels. The findingshttps://test.maltsci.com/en/paper/pmid/24584096/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24584096/The rapid adoption of CRISPR technology for targeted genome editing has revolutionized biological research by enabling efficient and customizable modifications of genes in various organisms, includinghttps://test.maltsci.com/en/paper/pmid/25263330/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25263330/This study introduces a Cre-dependent Cas9 knockin mouse to facilitate in vivo genome editing, demonstrating effective editing in various cell types using different delivery methods. The research highhttps://test.maltsci.com/en/paper/pmid/34613616/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34613616/This review discusses the advancements and clinical applications of chimeric antigen receptor (CAR) T-cell therapy, which has significantly improved treatment outcomes for hematologic malignancies, pahttps://test.maltsci.com/en/paper/pmid/38685134/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38685134/The AJCC staging system for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has been updated to incorporate new classifications and advancements in diagnostic and therapeutic technologies, dishttps://test.maltsci.com/en/paper/pmid/40457408/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40457408/This review examines the transformative role of artificial intelligence (AI) in oncology, focusing on its applications in early cancer detection, personalized treatment planning, and patient managemenhttps://test.maltsci.com/en/paper/pmid/33156543/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33156543/This study highlights the need for cancer registries to incorporate staging data after neoadjuvant therapy (NAT), as current practices only partially capture this information, potentially leading to mhttps://test.maltsci.com/en/paper/pmid/33592120/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33592120/Gastric cancer, a leading cause of cancer mortality worldwide, exhibits biological differences between Eastern and Western tumors that complicate treatment standardization; however, advancements in trhttps://test.maltsci.com/en/paper/pmid/34082136/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34082136/This paper reviews the evolution of de novo molecular design strategies in drug discovery, highlighting advancements facilitated by machine learning and artificial intelligence over the past thirty yehttps://test.maltsci.com/en/paper/pmid/37149643/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37149643/This review discusses the advancements in chimeric antigen receptor (CAR) T-cell therapy and the role of single-cell sequencing technologies in addressing the challenges associated with its clinical ahttps://test.maltsci.com/en/paper/pmid/36415536/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36415536/This systematic literature review examines the application of deep learning (DL) technologies in drug discovery, highlighting their role in areas such as drug-target interactions and side effect predihttps://test.maltsci.com/en/paper/pmid/26544934/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26544934/This Primer reviews recent advancements in single-cell sequencing, highlighting its potential to uncover somatic mutations and cell type composition while addressing the significant technical challenghttps://test.maltsci.com/en/paper/pmid/27851739/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27851739/This study demonstrates the development of a fully defined culture system using modular synthetic hydrogel networks to optimize the extracellular matrix (ECM) conditions for intestinal stem cell (ISC)https://test.maltsci.com/en/paper/pmid/24553385/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24553385/This study demonstrates that circulating tumor DNA (ctDNA) can detect tumors noninvasively in over 75% of patients with advanced cancers, while showing variable detection rates in localized tumors andhttps://test.maltsci.com/en/paper/pmid/31061481/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31061481/CIBERSORTx is a novel machine learning method that enhances the CIBERSORT framework to infer cell-type-specific gene expression profiles from bulk tissue transcriptomes, making it applicable to largehttps://test.maltsci.com/en/paper/pmid/23064118/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23064118/mRNA vaccines represent a novel and flexible vaccine platform that combines safety with the ability to elicit a strong immune response without MHC haplotype restrictions, making them suitable for divehttps://test.maltsci.com/en/paper/pmid/30531897/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30531897/This study demonstrates the application of the uniform manifold approximation and projection (UMAP) technique in analyzing high-dimensional biological data from mass cytometry and single-cell RNA sequhttps://test.maltsci.com/en/paper/pmid/40578358/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40578358/Stahl et al. reveal that a CSF1R+ myelo-monocytic population impairs the efficacy of CAR T cell therapy in B cell lymphoma, highlighting a critical resistance mechanism. Their findings demonstrate thahttps://test.maltsci.com/en/paper/pmid/25959774/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25959774/This study reveals that disruptions in topologically associated domains (TADs) can lead to pathological limb malformations in humans by altering the regulatory architecture of the WNT6/IHH/EPHA4/PAX3https://test.maltsci.com/en/paper/pmid/27124452/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27124452/This study utilized single-cell RNA sequencing to analyze 4,645 cells from melanoma tumors, revealing significant transcriptional heterogeneity among malignant cells related to cell cycle, spatial conhttps://test.maltsci.com/en/paper/pmid/36097221/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36097221/This study explores the mechanisms behind the varying responses to CD19-targeting CAR-T cell therapies in patients with large B cell lymphoma by analyzing single-cell transcriptomes from treated indivhttps://test.maltsci.com/en/paper/pmid/28232471/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28232471/This study uncovers the heterogeneity of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDA), identifying distinct subpopulations that differ in their expression of α-smoothhttps://test.maltsci.com/en/paper/pmid/30410070/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30410070/This review explores the diverse roles of bilin-binding photoreceptors in cyanobacteria, which enable these organisms to sense and respond to varying light conditions, thereby regulating essential prohttps://test.maltsci.com/en/paper/pmid/39147831/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/39147831/This study investigates the potential of circulating tumor DNA (ctDNA) sequencing to enhance risk stratification for cancer-associated venous thromboembolism (VTE) in patients with various cancers, rehttps://test.maltsci.com/en/paper/pmid/33720637/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33720637/This phase 2 trial evaluated donanemab, an antibody targeting amyloid-β, in patients with early symptomatic Alzheimer''s disease, finding that it improved cognitive and daily living abilities comparedhttps://test.maltsci.com/en/paper/pmid/23992846/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23992846/This study presents a novel genome editing approach utilizing a Cas9 nickase mutant combined with paired guide RNAs to achieve targeted double-strand breaks while significantly reducing off-target effhttps://test.maltsci.com/en/paper/pmid/30954475/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30954475/This study introduces DoubletFinder, a computational tool designed to detect doublets in single-cell RNA sequencing data based solely on gene expression, addressing the issue of technical artifacts thhttps://test.maltsci.com/en/paper/pmid/19589993/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/19589993/The decline in pharmaceutical research on natural products over the past 15 years has coincided with reduced new drug approvals and the looming expiration of patents on key medications. However, advanhttps://test.maltsci.com/en/paper/pmid/36211133/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36211133/An international security conference investigated the potential misuse of artificial intelligence (AI) in drug discovery for the creation of biochemical weapons, highlighting a critical concern in modhttps://test.maltsci.com/en/paper/pmid/37550574/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37550574/This study introduces DyNAtrix, a fully synthetic hydrogel that self-assembles using DNA libraries to create a dynamic, programmable matrix with tunable viscoelastic properties, mimicking the mechanichttps://test.maltsci.com/en/paper/pmid/28622506/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28622506/This research highlights the significance of various RNA chemical modifications, particularly N6-methyladenosine (m6A), in regulating mRNA metabolism and function, emphasizing their roles in the mRNAhttps://test.maltsci.com/en/paper/pmid/38423389/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38423389/The ET-FES trial assessed the use of 18F-fluoroestradiol (FES) PET/CT as a predictive biomarker for treatment response in estrogen receptor-positive, HER2-negative metastatic breast cancer, revealinghttps://test.maltsci.com/en/paper/pmid/29932424/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29932424/This study introduces EEGNet, a compact convolutional neural network designed to classify EEG signals across multiple brain-computer interface (BCI) paradigms, demonstrating superior generalization anhttps://test.maltsci.com/en/paper/pmid/33378609/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33378609/The phase 3 trial of the mRNA-1273 vaccine demonstrated a 94.1% efficacy in preventing symptomatic Covid-19 among high-risk individuals, with severe disease occurring only in the placebo group. The fihttps://test.maltsci.com/en/paper/pmid/24553386/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24553386/This study reports on 16 patients with relapsed or refractory B cell acute lymphoblastic leukemia (B-ALL) treated with autologous T cells expressing the 19-28z chimeric antigen receptor targeting CD19https://test.maltsci.com/en/paper/pmid/30886654/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30886654/This meta-analysis of 22 studies involving 262 patients assesses the efficacy of chimeric antigen receptor T (CAR-T) cell therapy in solid tumors, revealing an overall response rate of only 9%, with nhttps://test.maltsci.com/en/paper/pmid/23360964/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23360964/This study demonstrates that the CRISPR-Cas system can effectively induce targeted genetic modifications in zebrafish embryos, achieving efficiencies comparable to traditional methods like zinc fingerhttps://test.maltsci.com/en/paper/pmid/33552558/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33552558/This review discusses the potential of engineered matrices to enhance organoid cultures, which better replicate human organ biology compared to traditional 2D systems. By optimizing the biochemical anhttps://test.maltsci.com/en/paper/pmid/30837696/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30837696/This article reviews the potential of synthetic biology to enhance engineered immune-cell-based therapies for B cell malignancies by developing gene circuit therapies that target cancer cells specifichttps://test.maltsci.com/en/paper/pmid/34616030/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34616030/This study explores the application of synthetic biology in engineering cells with synthetic gene circuits to create novel therapeutics that can precisely target disease biomarkers, offering advantagehttps://test.maltsci.com/en/paper/pmid/30941347/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30941347/This paper reviews advancements in developing in vitro vascular structures to enhance the functional complexity and scalability of organoids for drug discovery and regenerative medicine. By integratinhttps://test.maltsci.com/en/paper/pmid/33623712/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33623712/This review highlights the potential of engineering approaches to overcome limitations in traditional organoid culture, such as high variability and restricted access, which hinder their application ihttps://test.maltsci.com/en/paper/pmid/29305085/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29305085/This paper reviews the current strategies for the in vivo delivery of CRISPR-Cas gene editing components, emphasizing the importance of efficient delivery methods for the therapeutic potential of theshttps://test.maltsci.com/en/paper/pmid/32068901/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32068901/This article addresses the significant disparities in cancer survival rates globally, emphasizing the barriers to access essential cancer medicines, such as high costs, inappropriate usage, and weak hhttps://test.maltsci.com/en/paper/pmid/32533130/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32533130/This review explores the dual role of host epigenetic and epitranscriptomic modifications in regulating viral gene expression, highlighting how these processes can both inhibit and facilitate viral rehttps://test.maltsci.com/en/paper/pmid/30376182/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30376182/This research highlights the urgent need for coordinated and personalized care for cancer survivors, driven by increasing survivor populations, provider shortages, and rising healthcare costs. The authttps://test.maltsci.com/en/paper/pmid/40462147/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40462147/This study establishes a Matrigel-based three-dimensional (3D) organoid culture model from patient-derived conditionally reprogrammed cell lines, demonstrating that these organoids preserve the molecuhttps://test.maltsci.com/en/paper/pmid/32908314/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32908314/This study presents a novel three-dimensional organoid culture system for isolating and maintaining human trophoblast cells from first-trimester placentas, enabling long-term growth and differentiatiohttps://test.maltsci.com/en/paper/pmid/30573816/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30573816/This study investigates transcriptional variations in kidney organoids derived from human pluripotent stem cells, revealing significant batch-to-batch differences primarily related to nephron maturatihttps://test.maltsci.com/en/paper/pmid/33548389/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33548389/This review highlights the growing significance of exosomes and extracellular vesicles as a promising platform for liquid biopsy in cancer, offering potential advantages for early detection, treatmenthttps://test.maltsci.com/en/paper/pmid/30925935/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30925935/This review highlights the critical role of exosomes in the hypoxic tumor microenvironment, where their interactions between cancer and stromal cells contribute to tumor aggressiveness and treatment rhttps://test.maltsci.com/en/paper/pmid/30457670/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30457670/This article examines the low referral and uptake rates of cancer rehabilitation despite its benefits, drawing parallels with the successful growth strategies of palliative care in oncology. It identihttps://test.maltsci.com/en/paper/pmid/33497263/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33497263/This review examines the genetic underpinnings of Alzheimer''s disease (AD), highlighting how advancements in understanding both hereditary and sporadic forms of the disorder have elucidated its pathophttps://test.maltsci.com/en/paper/pmid/24336569/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24336569/This study presents a pooled, loss-of-function genetic screening method utilizing a genome-scale lentiviral sgRNA library to explore essential genes and drug resistance mechanisms in human cell lineshttps://test.maltsci.com/en/paper/pmid/30038414/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30038414/This study introduces a novel 3D organoid model, the neoplastic cerebral organoid (neoCOR), which successfully mimics brain tumorigenesis by incorporating specific oncogenic mutations through advancedhttps://test.maltsci.com/en/paper/pmid/25430774/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25430774/The CRISPR-Cas9 system has revolutionized genome engineering across various organisms, facilitating precise modifications and regulation of genomic loci. This technological advancement not only enhanchttps://test.maltsci.com/en/paper/pmid/24157548/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24157548/This study presents a comprehensive toolkit for using the Cas9 nuclease for precise genome editing in mammalian cells through nonhomologous end joining (NHEJ) and homology-directed repair (HDR), whilehttps://test.maltsci.com/en/paper/pmid/36280722/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36280722/This study presents a novel and scalable method for the long-term culture and maturation of organoids, enabling the creation of radial arrays from stem cell suspensions without passaging, which enhanchttps://test.maltsci.com/en/paper/pmid/31114875/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31114875/GEPIA2 is an enhanced version of the original GEPIA web server, providing advanced gene expression analysis with higher resolution by integrating data from 198,619 isoforms and 84 cancer subtypes. Thihttps://test.maltsci.com/en/paper/pmid/33538338/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33538338/This article updates the global cancer burden using GLOBOCAN 2020 data, revealing approximately 19.3 million new cases and nearly 10 million deaths, with female breast cancer now the most diagnosed, whttps://test.maltsci.com/en/paper/pmid/40148602/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40148602/This research addresses the critical issue of antibacterial resistance by highlighting the need for innovative drug discovery beyond existing antibiotic classes, focusing on new direct-acting agents thttps://test.maltsci.com/en/paper/pmid/40845838/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40845838/This study investigates the potential of deleting signal peptide peptidase-like 3 (SPPL3) to enhance glycan-mediated immune evasion in allogeneic CAR-T cell therapy, demonstrating that SPPL3-null, TCRhttps://test.maltsci.com/en/paper/pmid/26175682/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26175682/The study introduces the GRaph thEoreTical Network Analysis (GRETNA) toolbox, an open-source Matlab-based platform designed for imaging connectomics that facilitates the construction and analysis of bhttps://test.maltsci.com/en/paper/pmid/23747961/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23747961/This study introduces a novel groupwise graph-theory-based parcellation method for defining nodes in network analysis, addressing limitations of existing atlases by ensuring functional homogeneity withttps://test.maltsci.com/en/paper/pmid/32651318/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32651318/This study reviews the associations between heavy metals—lead, cadmium, and manganese—and the risk of Alzheimer''s disease and related dementias, highlighting that these neurotoxicants can negatively ihttps://test.maltsci.com/en/paper/pmid/23575629/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23575629/This study addresses the unstable supply of artemisinin, a critical antimalarial drug, by utilizing synthetic biology to develop high-yielding strains of Saccharomyces cerevisiae for the efficient prohttps://test.maltsci.com/en/paper/pmid/20440275/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/20440275/This review examines the complex bacterial responses to antibiotic treatments that lead to cell death, highlighting the inhibition of essential cellular processes by bactericidal antibiotics and the ahttps://test.maltsci.com/en/paper/pmid/38082131/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38082131/This study investigates the impact of urban green spaces on mental health and well-being, highlighting a significant correlation between access to these areas and reduced levels of stress and anxietyhttps://test.maltsci.com/en/paper/pmid/31373349/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31373349/This review discusses the emerging role of circulating tumor DNA (ctDNA) as a non-invasive liquid biopsy tool for genotyping solid cancers, monitoring tumor dynamics, and detecting drug resistance, hihttps://test.maltsci.com/en/paper/pmid/35396481/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35396481/This Perspective highlights the use of organoids derived from human pluripotent stem cells and adults to investigate the tropism of SARS-CoV-2, the host immune response, and facilitate drug discoveryhttps://test.maltsci.com/en/paper/pmid/41225057/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41225057/This review highlights the potential of organoids, three-dimensional structures derived from stem cells, as advanced models for drug discovery due to their ability to mimic human tissue complexity andhttps://test.maltsci.com/en/paper/pmid/32636524/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32636524/This review highlights the emerging role of human organoids—stem cell-derived 3D culture systems—as powerful models for studying human biology and disease, addressing limitations of traditional animalhttps://test.maltsci.com/en/paper/pmid/32639044/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32639044/The American Cancer Society (ACS) recommends routine HPV vaccination for children aged 9 to 12 years to enhance vaccination rates and prevent more cancers, urging healthcare providers to initiate vacchttps://test.maltsci.com/en/paper/pmid/29131160/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29131160/This study presents a novel organoid culture system that enables the long-term propagation of primary liver cancer organoids from common subtypes, preserving their histological and genomic characterishttps://test.maltsci.com/en/paper/pmid/38424470/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38424470/This review highlights the significant role of chronic immune activation, particularly through brain-resident macrophages known as microglia, in the pathogenesis of Alzheimer’s disease (AD), alongsidehttps://test.maltsci.com/en/paper/pmid/36081506/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36081506/This paper discusses Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS), a serious neurotoxic side effect of chimeric antigen receptor (CAR)-T cell therapy, which, despite its effectiveneshttps://test.maltsci.com/en/paper/pmid/34312554/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34312554/This observational study demonstrates that heterologous priming with the ChAdOx1 nCoV-19 vector vaccine followed by mRNA boosting significantly enhances spike-specific IgG, neutralizing antibodies, anhttps://test.maltsci.com/en/paper/pmid/34214473/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34214473/This study investigates the efficacy of SARS-CoV-2 mRNA vaccines in cancer patients, revealing that 94% of the 131 participants achieved seroconversion after two doses, though those with hematologicalhttps://test.maltsci.com/en/paper/pmid/33125860/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33125860/This paper explores how the tumor microenvironment (TME) influences the metabolism of immune cells, which in turn affects their differentiation and function. By highlighting recent advancements in methttps://test.maltsci.com/en/paper/pmid/38096276/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38096276/This research investigates the efficacy of antibodies that target amyloid-β aggregates in slowing the cognitive decline associated with Alzheimer''s disease. The findings suggest that these antibodieshttps://test.maltsci.com/en/paper/pmid/40035554/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40035554/This review discusses the potential of hydrogel-based electrodes for brain-computer interfaces (BCIs) as a solution to the limitations of traditional rigid electrodes, which face issues like foreign bhttps://test.maltsci.com/en/paper/pmid/30661858/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30661858/This research highlights that nearly 50% of adults over 60 experience sleep disturbances, which are linked to cognitive decline and an increased risk of Alzheimer''s disease through mechanisms involvinhttps://test.maltsci.com/en/paper/pmid/20192734/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/20192734/This study highlights that while the yield of major food grain crops has significantly increased over the past 50 years, future enhancements will largely depend on improving photosynthetic efficiency,https://test.maltsci.com/en/paper/pmid/41028170/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41028170/This review discusses the innovative approach of in vivo CAR-T cell engineering, which aims to enhance the accessibility and efficacy of CAR-T cell therapies for hematological malignancies and potentihttps://test.maltsci.com/en/paper/pmid/25830891/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25830891/This study explores the use of Staphylococcus aureus Cas9 (SaCas9), a smaller alternative to Streptococcus pyogenes Cas9 (SpCas9), demonstrating that SaCas9 can achieve genome editing efficiencies comhttps://test.maltsci.com/en/paper/pmid/31690864/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31690864/This study investigates the impact of urban green spaces on mental health, highlighting their role in reducing stress and enhancing overall well-being. The findings suggest that increasing access to ghttps://test.maltsci.com/en/paper/pmid/32333836/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32333836/This study provides evidence that human recombinant soluble ACE2 (hrsACE2) significantly inhibits SARS-CoV-2 growth in vitro, reducing viral recovery from Vero cells by 1,000-5,000 times, while mousehttps://test.maltsci.com/en/paper/pmid/24048123/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24048123/This study identifies two distinct phenotypes of tumor microenvironments that enable cancer cells to evade immune recognition by CD8(+) T cells: one characterized by T cell inflammation and immune suppressionhttps://test.maltsci.com/en/paper/pmid/34129817/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34129817/This research focuses on the tumor immune microenvironment (TIME), highlighting the complex interactions between adaptive and innate immune cells that can both promote and inhibit tumor growth. The sthttps://test.maltsci.com/en/paper/pmid/32311776/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32311776/This review explores the growing role of patient-generated health data (PGHD) in oncology, highlighting its potential to enhance regulatory decisions and quality of care through improved symptom monithttps://test.maltsci.com/en/paper/pmid/38398742/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38398742/This paper examines the transformative role of artificial intelligence (AI) in drug discovery, highlighting its applications in drug design, target identification, and virtual screening, while also dihttps://test.maltsci.com/en/paper/pmid/28252003/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28252003/This review highlights the potential of liquid biopsies, particularly circulating cell-free tumor DNA (ctDNA), as a more accurate and dynamic approach for profiling solid tumors compared to traditionahttps://test.maltsci.com/en/paper/pmid/34751943/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34751943/This research highlights the challenges faced by low- and middle-income countries (LMICs) in cancer care, where patients often turn to traditional, complementary, and integrative medicine (TCIM) due thttps://test.maltsci.com/en/paper/pmid/34383300/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34383300/This review discusses the growing interest in intermittent fasting (IF) as an alternative to chronic caloric restriction (CR) for cancer prevention and treatment, highlighting its popularity among pathttps://test.maltsci.com/en/paper/pmid/38174605/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38174605/This study highlights the significant advancements in genomic testing for cancer over the past decade, which have identified driver mutations that can inform targeted therapies and enhance personalizehttps://test.maltsci.com/en/paper/pmid/38424454/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38424454/This research highlights the complexity of Alzheimer''s disease (AD), emphasizing that its multifactorial nature—shaped by various genetic, environmental, and clinical factors—suggests it functions morhttps://test.maltsci.com/en/paper/pmid/31665002/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31665002/This article highlights the rapid advancement of artificial intelligence (AI) in healthcare, while addressing significant challenges in translating these technologies from research to clinical practichttps://test.maltsci.com/en/paper/pmid/36323230/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36323230/Chen et al. demonstrate that elevated intratumoral potassium ions limit the plasticity of tumor-associated macrophages (TAMs) in the tumor microenvironment, revealing a crucial link between ion channehttps://test.maltsci.com/en/paper/pmid/36449413/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36449413/This phase 3 trial investigated lecanemab, a monoclonal antibody targeting amyloid-beta, in 1795 participants with early Alzheimer''s disease, revealing it significantly reduced amyloid burden and resuhttps://test.maltsci.com/en/paper/pmid/34394960/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34394960/This review explores the development and clinical application of lipid nanoparticles as delivery systems for mRNA therapeutics, which have proven effective in combating diseases such as COVID-19. It hhttps://test.maltsci.com/en/paper/pmid/35594500/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35594500/This review highlights the potential of CRISPR/Cas9 gene editing as a therapeutic approach for genetic diseases and cancers, emphasizing the challenges in delivering its components safely and effectivhttps://test.maltsci.com/en/paper/pmid/41372534/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41372534/This study emphasizes the transformative potential of liquid biopsies, particularly through the analysis of circulating cell-free DNA (cfDNA), in enhancing cancer detection and monitoring in precisionhttps://test.maltsci.com/en/paper/pmid/28233803/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28233803/Recent advancements in genomic and molecular techniques are enhancing the capabilities of circulating tumor DNA (ctDNA) for both research purposes and clinical applications as a ''liquid biopsy'' in canhttps://test.maltsci.com/en/paper/pmid/24449238/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24449238/This research highlights the limitations of traditional tumor tissue sampling for detecting somatic genetic alterations in oncology, emphasizing the emerging role of circulating cell-free DNA (cfDNA)https://test.maltsci.com/en/paper/pmid/30382599/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30382599/This review highlights the transformative potential of liquid biopsy in cancer treatment, emphasizing its minimally invasive nature and ability to provide real-time molecular profiling through the anahttps://test.maltsci.com/en/paper/pmid/31269959/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31269959/Hepatocellular carcinoma (HCC) is a prevalent cancer with significant mortality, and traditional invasive biopsies often fail to capture tumor heterogeneity and progression, highlighting the need forhttps://test.maltsci.com/en/paper/pmid/31610267/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31610267/This review highlights the potential of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) as minimally-invasive biomarkers for diagnosis, prognostication, and monitoring in ovarian canchttps://test.maltsci.com/en/paper/pmid/34224369/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34224369/This study investigates the potential of liquid biopsies to identify metastatic colorectal cancer patients suitable for re-treatment with anti-EGFR therapy after prior resistance. In a phase II trial,https://test.maltsci.com/en/paper/pmid/32289272/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32289272/This study explores the use of liquid biopsies, particularly circulating tumor DNA and circulating tumor cells from blood samples, as predictive biomarkers for personalized cancer therapy and for monihttps://test.maltsci.com/en/paper/pmid/36096847/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36096847/This review highlights the growing significance of liquid biopsies, particularly circulating extracellular nucleic acids and circulating tumor cells, in precision oncology, emphasizing their role in chttps://test.maltsci.com/en/paper/pmid/33811121/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33811121/This research highlights the growing significance of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) as promising biomarkers in cancer diagnostics and treatment monitoring over the lashttps://test.maltsci.com/en/paper/pmid/21889923/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21889923/This study developed optimized culture conditions for expanding epithelial organoids from mouse colon and human intestinal tissues, revealing that the addition of specific growth factors enables indefhttps://test.maltsci.com/en/paper/pmid/29385376/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29385376/This phase 1 trial evaluated the safety and efficacy of 19-28z CAR T cells in adults with relapsed B-cell acute lymphoblastic leukemia (ALL), finding an 83% complete remission rate and a median overalhttps://test.maltsci.com/en/paper/pmid/39141854/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/39141854/This study investigates the long-term use of an implanted brain-computer interface (BCI) for communication in a patient with advanced amyotrophic lateral sclerosis (ALS) over seven years, revealing thhttps://test.maltsci.com/en/paper/pmid/35164788/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35164788/This review discusses the pivotal role of abnormal N6-methyladenosine (m6A) modification in cancer development and prognosis, highlighting its potential as a target for novel anticancer therapies. Ithttps://test.maltsci.com/en/paper/pmid/31269428/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31269428/This study explores the role of tumor-associated macrophages (TAMs) in the tumor microenvironment, highlighting their dual function in promoting tumor growth and therapy resistance while also exhibitihttps://test.maltsci.com/en/paper/pmid/30082906/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30082906/In 2017, CAR T cell therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia became the first gene therapy approved in the USA, demonstrating high response rates but also significant toxicithttps://test.maltsci.com/en/paper/pmid/40232267/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40232267/Peripheral T-cell lymphomas (PTCL) demonstrate unique sensitivity to various epigenetically targeted drugs, including histone deacetylase inhibitors, EZH2, and DNMT3 inhibitors, prompting explorationhttps://test.maltsci.com/en/paper/pmid/38233503/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38233503/This study introduces DoTA-seq, a novel droplet microfluidics-based method for high-throughput single-cell sequencing, enabling the analysis of genetic heterogeneity in microbial populations. The methhttps://test.maltsci.com/en/paper/pmid/20371345/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/20371345/This research highlights the critical role of matrix metalloproteinases (MMPs) in cancer, revealing how their altered proteolytic activity contributes to tumor growth, metastasis, and modulation of thhttps://test.maltsci.com/en/paper/pmid/32807981/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32807981/This review highlights the escalating threat of antibiotic resistance due to bacterial biofilm formation on medical devices, which complicates treatment of infections. It discusses the potential of nahttps://test.maltsci.com/en/paper/pmid/31283845/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31283845/This research highlights the ongoing challenges of mesothelioma, particularly in developing countries where asbestos exposure remains prevalent, leading to inaccurate diagnoses and treatment complicathttps://test.maltsci.com/en/paper/pmid/33504580/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33504580/This review discusses how metabolic reprogramming in cancer cells is influenced by both intrinsic mechanisms, driven by oncogenic alterations, and extrinsic factors from the tumor microenvironment, whhttps://test.maltsci.com/en/paper/pmid/26321679/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26321679/This study reveals that tumors metabolically restrict T cells by consuming glucose, which reduces their mTOR activity and IFN-γ production, thereby facilitating tumor growth. Importantly, checkpoint bhttps://test.maltsci.com/en/paper/pmid/33982817/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33982817/This paper reviews the intricate relationship between cancer, its therapies, and metabolism, emphasizing the role of metabolomics in understanding these interactions at both cellular and systemic levehttps://test.maltsci.com/en/paper/pmid/40410356/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40410356/This review highlights the ecological interactions that influence microbial community structure and function in diverse fermented foods, emphasizing the role of both selected and autochthonous microorhttps://test.maltsci.com/en/paper/pmid/16873959/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/16873959/This study investigates the morphological and morphometric changes of mitochondria in neurons from various brain regions affected by Alzheimer''s disease, revealing significant alterations such as reduhttps://test.maltsci.com/en/paper/pmid/27315476/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27315476/Recent advancements in 3D culture technology have enabled embryonic and adult stem cells to form organoids that mimic the structural and functional properties of various human organs, offering a valuahttps://test.maltsci.com/en/paper/pmid/35302652/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35302652/This review highlights the critical role of pharmacogenomics in enhancing personalized oncology care by integrating germline genetic variants with somatic genomic information, which can significantlyhttps://test.maltsci.com/en/paper/pmid/33431035/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33431035/This review highlights the evolution of electronic molecular representations crucial for computational analysis in drug discovery, emphasizing their significance in the context of AI-driven methodologhttps://test.maltsci.com/en/paper/pmid/36192757/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36192757/This study introduces a novel GLuc reporter mouse model that enables efficient monitoring of tumor growth through the measurement of luciferase secreted into the blood, facilitating early detection ofhttps://test.maltsci.com/en/paper/pmid/33497262/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33497262/This review discusses the dual roles of monocytes in cancer, highlighting their capacity to either support immune suppression or activate antitumor responses, influenced by the tumor microenvironment.https://test.maltsci.com/en/paper/pmid/12353258/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/12353258/This review highlights the significant differences in tumor microenvironments compared to normal tissues, particularly focusing on chaotic vasculature leading to hypoxia and acidic conditions that affhttps://test.maltsci.com/en/paper/pmid/33632261/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33632261/This review highlights the potential of mRNA vaccines as a powerful platform for cancer immunotherapy, emphasizing their ability to efficiently express tumor antigens and stimulate immune responses. Dhttps://test.maltsci.com/en/paper/pmid/33593376/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33593376/This paper discusses the advancements in mRNA vaccines, highlighting their potential to combat cancer and viral diseases through enhanced safety and efficacy achieved via sequence optimization and innhttps://test.maltsci.com/en/paper/pmid/29326426/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29326426/mRNA vaccines have emerged as a highly effective alternative to traditional vaccines due to their rapid development and potential for safe, low-cost production, although challenges related to mRNA stahttps://test.maltsci.com/en/paper/pmid/34433919/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34433919/This review explores the evolution and significance of mRNA vaccines, which transitioned from skepticism to clinical application, particularly highlighted during the rapid development in response to thttps://test.maltsci.com/en/paper/pmid/37726283/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37726283/This review highlights the significant advancements of mRNA vaccines, particularly their efficacy and safety demonstrated during the COVID-19 pandemic, and explores their potential applications acrosshttps://test.maltsci.com/en/paper/pmid/34648302/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34648302/This study investigates the durability of immune memory following mRNA vaccination against SARS-CoV-2, revealing that while antibody levels decline, they remain detectable for six months, and functionhttps://test.maltsci.com/en/paper/pmid/33771389/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33771389/This review highlights the growing significance of mRNA vaccines in public health, particularly as a response to infectious diseases like Covid-19, and emphasizes their potential for treating varioushttps://test.maltsci.com/en/paper/pmid/31473352/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31473352/MRtrix3 is an open-source software package designed for the processing, analysis, and visualization of medical images, particularly focusing on brain studies through diffusion MRI. This article highlihttps://test.maltsci.com/en/paper/pmid/31800160/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31800160/This study explores the potential of chimeric antigen receptor (CAR) T cell therapy targeting MUC1 for treating head and neck squamous cell carcinoma (HNSCC), addressing challenges such as tumor struchttps://test.maltsci.com/en/paper/pmid/34281357/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34281357/This study highlights myocarditis as a rare complication following COVID-19 mRNA vaccination, particularly in young males, with reported rates of approximately 12.6 cases per million doses. Despite thhttps://test.maltsci.com/en/paper/pmid/24284625/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24284625/This study reveals that the m(6)A modification in mRNA is recognized by the YTHDF2 protein, which regulates mRNA degradation by directing mRNA from the translatable pool to decay sites, thus influencihttps://test.maltsci.com/en/paper/pmid/40033293/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40033293/This review discusses the potential of nanomedicines, particularly when combined with nanobodies, to improve cancer diagnosis and treatment by enhancing the precision of drug and imaging delivery whilhttps://test.maltsci.com/en/paper/pmid/33478109/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33478109/This review discusses the pivotal role of lipid nanoparticle delivery systems in the effectiveness of mRNA vaccines for SARS-CoV-2, highlighting their dual function in mRNA expression and as adjuvantshttps://test.maltsci.com/en/paper/pmid/32294554/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32294554/This review discusses the integration of nanotechnology into chimeric antigen receptor (CAR) T-cell therapy to address the challenges associated with its complex manufacturing and limited efficacy inhttps://test.maltsci.com/en/paper/pmid/40747084/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40747084/This research highlights the transformative potential of mRNA vaccines in combating infectious diseases and cancers, emphasizing their advantages over traditional vaccines, such as rapid design and hihttps://test.maltsci.com/en/paper/pmid/25792098/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25792098/This research highlights that Alzheimer''s disease involves significant interactions between neuronal and immunological processes, where misfolded proteins activate microglia and astroglia, leading tohttps://test.maltsci.com/en/paper/pmid/33140239/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33140239/This paper discusses the neurological toxicity associated with chimeric antigen receptor (CAR)-T cell therapy, specifically focusing on immune effector cell-associated neurotoxicity syndrome (ICANS),https://test.maltsci.com/en/paper/pmid/26700397/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26700397/This review explores the dual roles of neutrophils in the tumor microenvironment, highlighting their involvement in both promoting and inhibiting cancer progression through mechanisms of recruitment ahttps://test.maltsci.com/en/paper/pmid/34385685/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34385685/This research highlights the transformative role of organotypic models in understanding cancer heterogeneity and advancing personalized medicine, specifically emphasizing the need for standardized prohttps://test.maltsci.com/en/paper/pmid/31059632/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31059632/This review explores the multifaceted nature of cognitive impairment in schizophrenia, highlighting its impact on treatment and prognosis while detailing the types of cognitive deficits, their neuroimhttps://test.maltsci.com/en/paper/pmid/33002206/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33002206/This systematic review highlights the significant underrepresentation of older adults in cancer clinical trials, despite their increasing numbers, due to various barriers and a lack of effective interhttps://test.maltsci.com/en/paper/pmid/24239590/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24239590/This research addresses the need for appropriate multivariate analysis methods in neuroimaging to interpret cognitive processes, highlighting the distinction between forward models, which accurately lhttps://test.maltsci.com/en/paper/pmid/24859528/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24859528/This study explores the use of primary organoid cultures from mouse colon, stomach, and pancreas to model cancer, revealing that pancreatic and gastric organoids develop dysplasia and adenocarcinoma whttps://test.maltsci.com/en/paper/pmid/32853404/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32853404/Onconephrology is an emerging nephrology subspecialty that addresses the complex relationship between kidney disease and cancer, including issues like drug-induced nephrotoxicity and electrolyte disorhttps://test.maltsci.com/en/paper/pmid/23643243/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23643243/This study demonstrates the efficiency of the CRISPR/Cas system in generating mice with simultaneous mutations in multiple genes, specifically achieving high disruption rates in five genes using coinjhttps://test.maltsci.com/en/paper/pmid/38486294/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38486294/This review highlights the potential of optical biosensors utilizing nanomaterials in liquid biopsy as a minimally invasive alternative to traditional tissue biopsy for early disease diagnosis and monhttps://test.maltsci.com/en/paper/pmid/33936776/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33936776/In an interview with Nature Reviews Materials, Donald Ingber discusses the ethical and scientific challenges of animal testing in biomedical research, emphasizing the need for human-relevant models tohttps://test.maltsci.com/en/paper/pmid/25035496/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25035496/This paper reviews the advancements in organoid technology, which leverages the self-organizing ability of vertebrate cells to create three-dimensional cultures from human and patient-derived stem celhttps://test.maltsci.com/en/paper/pmid/26797458/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26797458/This study presents a protocol for creating 3D prostate organoid cultures from healthy and metastatic prostate cancer tissues, which successfully replicate the cellular architecture of both normal andhttps://test.maltsci.com/en/paper/pmid/28756233/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28756233/This paper reviews recent advancements in host-microbe interaction studies using organoid cultures, emphasizing their utility in modeling infections like Zika virus and various bacterial and viral pathttps://test.maltsci.com/en/paper/pmid/31694835/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31694835/This study establishes patient-derived organoid models of non-small cell lung cancer (NSCLC) that closely mimic the histology, genomic features, and tumorigenicity of primary tumors, addressing the nehttps://test.maltsci.com/en/paper/pmid/30061675/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30061675/This study addresses the rising incidence of esophageal adenocarcinoma (EAC) and its low survival rates by developing clinically annotated organoid cultures that mimic the primary tumor''s genetic andhttps://test.maltsci.com/en/paper/pmid/32099092/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32099092/This review highlights the significance of organoid technology as a superior method for studying gastrointestinal cancers, which constitute a significant portion of global cancer cases, by preservinghttps://test.maltsci.com/en/paper/pmid/25557080/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25557080/This study establishes organoid models from both normal and neoplastic pancreatic tissues, highlighting their ability to mimic tumor progression and enabling genetic manipulation to explore pathways ihttps://test.maltsci.com/en/paper/pmid/30067989/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30067989/This study addresses the limitations of current in vitro models for hepatocellular carcinoma (HCC) by generating long-term organoid cultures from tumor biopsies, which maintain the tumor''s morphology,https://test.maltsci.com/en/paper/pmid/32654925/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32654925/This paper discusses the critical role of cellular interactions in the tumor microenvironment (TME) on cancer progression and treatment responses, highlighting the limitations of traditional 2D modelshttps://test.maltsci.com/en/paper/pmid/31171692/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31171692/This research explores the advancement of organoids, which are multicellular structures derived from adult organs or pluripotent stem cells, aiming to enhance their cellular complexity and functionalhttps://test.maltsci.com/en/paper/pmid/29692415/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29692415/Recent advancements in in vitro 3D culture technologies, particularly organoids, provide innovative and more physiological models for human cancer research, facilitating the translation of basic reseahttps://test.maltsci.com/en/paper/pmid/31853049/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31853049/This review highlights the use of organoid technology in immunological research to explore the interactions between epithelial cells and the immune system, which are often inadequately represented inhttps://test.maltsci.com/en/paper/pmid/31171693/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31171693/This review highlights the potential of organ-on-a-chip technology to enhance the production, control, and analysis of stem cell-derived organoids that mimic the structure and function of real organs,https://test.maltsci.com/en/paper/pmid/37325195/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37325195/This Primer discusses the significance of organoids as versatile in vitro models that mirror the complexity of human tissues, facilitating studies on development, disease, and personalized medicine. Ihttps://test.maltsci.com/en/paper/pmid/32964460/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32964460/This study underscores the significant global health threat posed by outdoor air pollution, particularly particulate matter, which is linked to increased lung cancer incidence and mortality, with hundhttps://test.maltsci.com/en/paper/pmid/35844299/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35844299/This review discusses the rapid advancement of chimeric antigen receptor T-cell (CAR-T) therapies, particularly their transformative impact on treating non-Hodgkin lymphoma, B-cell acute lymphoblastichttps://test.maltsci.com/en/paper/pmid/19221412/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/19221412/This review highlights the interconnectedness of Alzheimer''s disease and vascular dementia, suggesting they represent two extremes of a single pathological continuum influenced by oxidative stress. Thhttps://test.maltsci.com/en/paper/pmid/21113151/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21113151/This study investigates the relationship between Lgr5 stem cells and Paneth cells in the small intestine, revealing that Paneth cells provide critical niche signals that support the maintenance and prhttps://test.maltsci.com/en/paper/pmid/28332488/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28332488/Parkinson''s disease, the second-most common neurodegenerative disorder affecting a significant portion of the elderly population, is characterized by neuronal loss in the substantia nigra and α-synuclhttps://test.maltsci.com/en/paper/pmid/25904081/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25904081/This seminar reviews the complexities of Parkinson''s disease, highlighting its heterogeneous symptomatology that extends beyond classic motor features to include significant non-motor symptoms, and thhttps://test.maltsci.com/en/paper/pmid/33848468/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33848468/The paper discusses the rising prevalence of Parkinson''s disease, highlighting its multifactorial nature, with 3-5% attributed to genetic causes and various non-genetic risk factors significantly incrhttps://test.maltsci.com/en/paper/pmid/38428389/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38428389/This review highlights the transformative impact of CRISPR-based genome editing technologies in life sciences and medicine, emphasizing their efficiency and programmability while addressing current lihttps://test.maltsci.com/en/paper/pmid/32990680/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32990680/This study investigates patient-derived organoid models for pancreatic ductal adenocarcinoma (PDAC), revealing a significant correlation between organoid drug response and in vivo tumor growth, alonghttps://test.maltsci.com/en/paper/pmid/28445469/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28445469/This study demonstrates the potential of using tumor-specific phylogenetic profiling of circulating tumor DNA (ctDNA) to non-invasively track early-stage non-small-cell lung cancer evolution and identhttps://test.maltsci.com/en/paper/pmid/33028993/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33028993/This study investigates the impact of environmental factors on the growth patterns of urban trees, highlighting the critical role of soil quality and water availability in enhancing tree health and rehttps://test.maltsci.com/en/paper/pmid/32997807/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32997807/The COVID-19 pandemic significantly disrupted cancer care delivery, prompting the University of California Cancer Consortium to adapt its management strategies amid varying regional impacts. This revihttps://test.maltsci.com/en/paper/pmid/25825364/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25825364/This review highlights the role of plant synthetic biology in enhancing traditional agriculture and enabling novel bioproduction by integrating engineering principles with plant biology. It discusseshttps://test.maltsci.com/en/paper/pmid/32895549/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32895549/This study addresses the challenge of poor long-term reliability in brain-computer interfaces (BCIs) for individuals with severe motor impairments by demonstrating that long-term closed-loop decoder ahttps://test.maltsci.com/en/paper/pmid/33432235/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33432235/This review explores how genetic drift and founder effects during population bottlenecks in arthropod vectors influence the evolution and spread of arboviruses, such as chikungunya and Zika virus, whihttps://test.maltsci.com/en/paper/pmid/35389792/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35389792/This study highlights the potential of single-cell technology in elucidating the genetic underpinnings of human diseases, enabling a more nuanced understanding of cellular heterogeneity and disease mehttps://test.maltsci.com/en/paper/pmid/27808276/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27808276/The discovery of reversible mRNA methylation, particularly N6-methyladenosine (m6A), has revealed a significant mechanism of post-transcriptional gene regulation in eukaryotes, enhancing mRNA metabolihttps://test.maltsci.com/en/paper/pmid/36038892/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36038892/This review discusses the metabolic reprogramming of cancer cells, particularly the alterations in lipid metabolism that are characteristic of aggressive tumors and associated with poor prognosis. Ithttps://test.maltsci.com/en/paper/pmid/40440380/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40440380/This research highlights the potential of combining advancements in aging science and artificial intelligence to accurately identify individuals at high risk for Alzheimer''s disease long before cognithttps://test.maltsci.com/en/paper/pmid/26460009/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26460009/This study demonstrates that tumor organoids can be successfully cultured from metastatic colorectal cancer biopsies, achieving a 71% success rate, and reveals that these organoids maintain the genetihttps://test.maltsci.com/en/paper/pmid/41407852/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41407852/This study assessed the prevalence of Alzheimer''s disease neuropathological changes (ADNCs) using phosphorylated tau in plasma samples from a Norwegian cohort aged over 57, revealing that ADNCs signifhttps://test.maltsci.com/en/paper/pmid/27096365/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27096365/This research introduces ''base editing,'' a novel genome-editing technique that allows for the precise conversion of one DNA base into another without inducing double-stranded DNA breaks, thereby overchttps://test.maltsci.com/en/paper/pmid/23761437/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23761437/This study presents a novel approach to controlling gene transcription using a Cas9 nuclease mutant, which can be engineered to function as a programmable transcription repressor or activator. This tehttps://test.maltsci.com/en/paper/pmid/33716680/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33716680/This review discusses the advancements in brain-computer interfaces (BCI), which bridge communication between the brain and external devices, thus enhancing human capabilities in areas like rehabilitahttps://test.maltsci.com/en/paper/pmid/25957691/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25957691/This study establishes tumor organoid cultures from colorectal carcinoma patients, demonstrating that these organoids retain key characteristics of the original tumors and reflect their genetic divershttps://test.maltsci.com/en/paper/pmid/31485032/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31485032/This study highlights the increasing recognition of protein post-translational modifications (PTMs) in bacteria, which, although occurring at lower frequencies than in eukaryotes, play crucial roles ihttps://test.maltsci.com/en/paper/pmid/34015860/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34015860/This study highlights significant disparities in lung cancer screening (LCS) among Black and socioeconomically disadvantaged individuals, identifying critical stages in the LCS pipeline where these grhttps://test.maltsci.com/en/paper/pmid/34255347/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34255347/This article reviews the clinical implications of radiation therapy (RT) side effects across various organ systems, emphasizing that while RT is essential for cancer treatment, it can cause significanhttps://test.maltsci.com/en/paper/pmid/27160350/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27160350/This study presents a rapid, low-cost diagnostic pipeline for detecting Zika virus RNA using cell-free, paper-based sensors that integrate isothermal amplification and toehold switch RNA sensors, achihttps://test.maltsci.com/en/paper/pmid/22596161/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22596161/This study investigates the potential of a neural interface system to enable individuals with long-standing tetraplegia to control a robotic arm for complex movements like reaching and grasping. The fhttps://test.maltsci.com/en/paper/pmid/24622617/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24622617/This Viewpoint article highlights the emerging significance of synthetic biology in clinical applications and biotechnology, emphasizing its achievements and the collaborative efforts of diverse scienhttps://test.maltsci.com/en/paper/pmid/32244193/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32244193/This review highlights the recent advancements in messenger RNA (mRNA) vaccines, which have shown significant efficacy against various cancers and infectious diseases, especially where traditional vachttps://test.maltsci.com/en/paper/pmid/33793968/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33793968/This review highlights the need for innovative treatments in pediatric oncology as traditional therapies reach their limits and long-term side effects become more evident among survivors. It discusseshttps://test.maltsci.com/en/paper/pmid/30643263/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30643263/This study investigates the role of specific macrophage subgroups in tissue fibrosis using single-cell RNA sequencing in a bleomycin-induced lung fibrosis mouse model. The researchers identified a novhttps://test.maltsci.com/en/paper/pmid/33972311/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33972311/This study provides a spatial atlas of lung adenocarcinoma (LUAD) evolution by performing single-cell RNA sequencing on 186,916 cells from early-stage LUADs and adjacent normal lung tissues, revealinghttps://test.maltsci.com/en/paper/pmid/26612492/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26612492/This paper reviews the rapid adoption of CRISPR-based methods for gene perturbation and their role in functional genomics, emphasizing important design considerations for genome editing experiments. Ihttps://test.maltsci.com/en/paper/pmid/31801986/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31801986/This article discusses the integration of artificial intelligence (AI) in small-molecule drug discovery, highlighting both the potential opportunities and the skepticism surrounding its impact on thehttps://test.maltsci.com/en/paper/pmid/31740769/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31740769/This research highlights the transformative potential of synthetic biology in agriculture, emphasizing its importance in addressing the significant challenges in food, fuel, and chemical production. Ihttps://test.maltsci.com/en/paper/pmid/37740191/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37740191/This review highlights the transformative potential of artificial intelligence (AI) in healthcare, emphasizing its applications in disease diagnosis, treatment recommendations, and patient engagementhttps://test.maltsci.com/en/paper/pmid/30948292/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30948292/This study systematically reviews the efficacy and safety of chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed or refractory hematologic and solid malignancies, finding that 54.https://test.maltsci.com/en/paper/pmid/30089906/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30089906/This study introduces RNA velocity as a method to estimate the time derivative of gene expression by distinguishing between unspliced and spliced mRNAs in single-cell RNA sequencing, allowing for predhttps://test.maltsci.com/en/paper/pmid/33301246/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33301246/This study evaluates the efficacy and safety of the BNT162b2 mRNA vaccine against Covid-19 in a large multinational trial involving over 43,000 participants, finding that it provides 95% protection aghttps://test.maltsci.com/en/paper/pmid/33673048/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33673048/This review examines the efficacy of SARS-CoV-2 mRNA vaccines in eliciting adaptive immune responses, crucial for protecting against COVID-19, highlighting findings from both pre-clinical animal studihttps://test.maltsci.com/en/paper/pmid/35354968/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35354968/This review examines the pathophysiology of SARS-CoV-2, highlighting how the virus can lead to severe pneumonia and acute respiratory distress syndrome (ARDS) through mechanisms such as dysfunctionalhttps://test.maltsci.com/en/paper/pmid/37532811/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37532811/This paper explores the integration of artificial intelligence (AI) in scientific discovery, highlighting advancements like self-supervised learning and geometric deep learning that enhance research ehttps://test.maltsci.com/en/paper/pmid/31634902/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31634902/This study presents prime editing, a precise genome editing technique that allows for the direct insertion of new genetic information at targeted DNA sites, using a modified Cas9 and engineered revershttps://test.maltsci.com/en/paper/pmid/33400957/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33400957/This review explores the evolution of mRNA vaccines, particularly in the context of COVID-19, highlighting advancements in RNA technology, self-assembly of nanoparticles, and key factors influencing mhttps://test.maltsci.com/en/paper/pmid/19329995/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/19329995/This study investigates the self-renewing capabilities of Lgr5(+) stem cells in the intestinal epithelium by establishing long-term culture conditions that allow single crypts to form multiple crypt fhttps://test.maltsci.com/en/paper/pmid/39048816/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/39048816/This study presents a comprehensive single-cell transcriptomic atlas of the aged human brain, analyzing 1.3 million cells from 283 post-mortem samples to uncover 76 distinct cell types, including spechttps://test.maltsci.com/en/paper/pmid/24925914/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24925914/This study utilized single-cell RNA sequencing to analyze 430 cells from five primary glioblastomas, revealing significant intratumoral heterogeneity in transcriptional programs related to oncogenesishttps://test.maltsci.com/en/paper/pmid/33412093/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33412093/Single-cell sequencing technologies are revolutionizing neuroscience by enabling detailed characterization of diverse brain cell types through transcriptomic and epigenomic assays, revealing gene reguhttps://test.maltsci.com/en/paper/pmid/32929221/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32929221/This review explores single-cell sequencing techniques for genomic, epigenomic, and transcriptomic profiling, highlighting their applications and the computational methods for integrating multiomics dhttps://test.maltsci.com/en/paper/pmid/35549970/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35549970/This review highlights the transformative role of single-cell sequencing (SCS) in understanding tumor metastasis, revealing its applications in analyzing tumor heterogeneity, drug resistance, and micrhttps://test.maltsci.com/en/paper/pmid/37592035/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37592035/The study introduces Monopogen, a computational tool that detects single-nucleotide variants (SNVs) from single-cell sequencing data, revealing how genetic backgrounds influence transcriptional and ephttps://test.maltsci.com/en/paper/pmid/31978343/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31978343/This study establishes long-term expanding organoids from snake venom glands, revealing that these organoids maintain high levels of toxin transcripts and distinct venom-expressing cell types, along whttps://test.maltsci.com/en/paper/pmid/32275330/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32275330/This study highlights the rarity and complexity of soft-tissue sarcomas (STS), which represent a small fraction of adult cancers and exhibit diverse behaviors and outcomes, underscoring the necessityhttps://test.maltsci.com/en/paper/pmid/22506599/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22506599/This research introduces SPAdes, a novel assembler designed for single-cell and multicell genomic data, addressing challenges like non-uniform read coverage and sequencing errors that hinder the assemhttps://test.maltsci.com/en/paper/pmid/30936566/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30936566/This study introduces a method to create spatially organized human forebrain organoids by incorporating a Sonic Hedgehog (SHH) protein gradient, which enables the establishment of in vivo-like topograhttps://test.maltsci.com/en/paper/pmid/40289115/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40289115/This review highlights the challenges of CAR T cell therapy in solid tumors, particularly the issues of tumor antigen heterogeneity and acquired resistance leading to immune escape and relapse. It emphttps://test.maltsci.com/en/paper/pmid/30155624/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30155624/This research highlights the critical role of cancer-associated fibroblasts (CAFs) within the tumor microenvironment, demonstrating how they support cancer growth by modulating immune responses and prhttps://test.maltsci.com/en/paper/pmid/33495561/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33495561/This review examines the high-resolution structures of RNA-dependent RNA polymerases from various negative-sense RNA viruses, highlighting their roles in genome replication and transcription. The findhttps://test.maltsci.com/en/paper/pmid/34244677/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34244677/This review discusses the structural insights gained from X-ray crystallography and cryogenic electron microscopy studies of retroviral DNA integration, focusing on the role of integrase and the formahttps://test.maltsci.com/en/paper/pmid/30555032/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30555032/This multicenter study investigated the incidence of Alzheimer''s disease and non-Alzheimer''s dementia among individuals with subjective cognitive decline (SCD), finding a higher dementia incidence inhttps://test.maltsci.com/en/paper/pmid/31485034/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31485034/This review highlights the significant role of organic sulfur compounds released by marine phytoplankton in facilitating nutrient cycling and interactions among marine microorganisms, particularly bachttps://test.maltsci.com/en/paper/pmid/37114458/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37114458/The American Joint Committee on Cancer (AJCC) has updated its staging system for anal cancer in version 9, incorporating new evidence and large data sets that reveal significant prognostic implicationhttps://test.maltsci.com/en/paper/pmid/37358310/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37358310/The study discusses the revisions in the AJCC staging system for appendiceal cancer, highlighting how survival analyses have informed the new version 9 criteria. It emphasizes the importance of differhttps://test.maltsci.com/en/paper/pmid/21102527/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21102527/This research highlights the significant impact of synonymous mutations on cellular processes, emphasizing the importance of understanding codon bias in both molecular evolution and biotechnology. Thehttps://test.maltsci.com/en/paper/pmid/32953138/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32953138/This review evaluates the limitations of Matrigel, a widely used basement-membrane matrix in cell culture, due to its variable composition and lack of reproducibility, which hinder its application inhttps://test.maltsci.com/en/paper/pmid/23656228/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23656228/This paper reviews the evolution of metabolic engineering and synthetic biology, highlighting how metabolic engineering focuses on optimizing microbial pathways for product synthesis, while synthetichttps://test.maltsci.com/en/paper/pmid/33571426/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33571426/This paper discusses the advancements in synthetic biology, which focuses on engineering new biological functions and has led to promising solutions for significant biomedical challenges, particularlyhttps://test.maltsci.com/en/paper/pmid/21885773/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21885773/This research highlights the rapid advancements in synthetic biology over the past decade, particularly in engineering biomolecular systems for biomedical applications such as therapies for infectioushttps://test.maltsci.com/en/paper/pmid/16954140/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/16954140/This paper reviews the advancements in synthetic biology, emphasizing the engineering-driven construction of complex biological systems through artificial gene networks, DNA synthesis, and protein enghttps://test.maltsci.com/en/paper/pmid/22577777/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/22577777/This review highlights the evolution of synthetic biology as an engineering discipline, emphasizing the transition from proof-of-concept designs to the establishment of core platforms that facilitatehttps://test.maltsci.com/en/paper/pmid/15995697/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/15995697/Synthetic biology encompasses two main approaches: one aims to create artificial life using unnatural molecules, while the other focuses on assembling interchangeable parts from natural systems to crehttps://test.maltsci.com/en/paper/pmid/36939293/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36939293/This review examines hormone receptor-positive and HER2-negative breast cancer, which constitutes 65%-70% of cases and primarily relies on endocrine therapy, particularly in combination with cyclin-dehttps://test.maltsci.com/en/paper/pmid/34252919/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34252919/This study utilizes a systems vaccinology approach to analyze the immune responses of 56 healthy volunteers vaccinated with the Pfizer-BioNTech mRNA vaccine, revealing robust neutralizing antibody prohttps://test.maltsci.com/en/paper/pmid/25838376/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25838376/This study reviews how stromal cells in the tumor microenvironment create immune privilege by preventing cytotoxic T cells from accessing cancer cells, which hampers effective immunotherapy. By undershttps://test.maltsci.com/en/paper/pmid/25319501/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/25319501/This phase 1 trial evaluated the feasibility and safety of CD19-CAR T cell therapy in children and young adults with refractory B-cell malignancies, finding that the maximum tolerated dose was 1×10^6https://test.maltsci.com/en/paper/pmid/34194012/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34194012/This review explores the complex interplay between oxidative stress, redox signaling, and various diseases, highlighting the mechanisms by which oxidative stress contributes to pathology and the limithttps://test.maltsci.com/en/paper/pmid/30364656/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30364656/This review highlights the emerging role of circulating tumor DNA (ctDNA) in precision medicine for cancer management, emphasizing its potential in monitoring tumor dynamics and predicting treatment rhttps://test.maltsci.com/en/paper/pmid/33567640/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33567640/This study highlights the effectiveness of nanobodies as antigen binding domains in chimeric antigen receptor (CAR) T therapy, demonstrating their ability to produce CAR-T and CAR-NK cells with signifhttps://test.maltsci.com/en/paper/pmid/27035812/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/27035812/Exosomes are small extracellular vesicles released by all cells, containing DNA, RNA, and proteins, and they play a potential role in cell communication and tumorigenesis by influencing angiogenesis,https://test.maltsci.com/en/paper/pmid/34714553/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34714553/This article reviews the epidemiology, pathogenesis, assessment, and management strategies for oral mucositis (OM), a painful complication of cancer therapies that significantly impacts patient qualithttps://test.maltsci.com/en/paper/pmid/2011243/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/2011243/The Neuropathology Task Force of the CERAD has established a standardized protocol for postmortem assessment of dementia, which defines diagnostic categories like "definite Alzheimer''s disease" to enhhttps://test.maltsci.com/en/paper/pmid/35969103/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35969103/This review highlights the significant impact of peritoneal metastasis (PM) on patient outcomes across various primary tumors, emphasizing the historical challenges in achieving durable symptom controhttps://test.maltsci.com/en/paper/pmid/33798667/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33798667/This review examines the rapid development and authorization of mRNA vaccines, specifically BNT162b2, mRNA-1273, and CVnCoV, during the COVID-19 pandemic, highlighting the scientific breakthroughs thahttps://test.maltsci.com/en/paper/pmid/21514250/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21514250/The workgroup commissioned by the National Institute on Aging and the Alzheimer''s Association revised the criteria for Alzheimer''s disease (AD) dementia to make them adaptable for both general healthchttps://test.maltsci.com/en/paper/pmid/38814103/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38814103/This review discusses the emergence of tumor-agnostic therapies, which focus on specific genetic anomalies rather than tumor origin, highlighting key milestones such as the FDA''s approval of pembrolizhttps://test.maltsci.com/en/paper/pmid/36917948/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36917948/This paper reviews the tumor microenvironment (TME), highlighting its critical role in cancer progression through its diverse cellular composition and interactions with tumor cells. Understanding theshttps://test.maltsci.com/en/paper/pmid/37031172/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37031172/This review highlights the significance of liquid biopsy in cancer research, focusing on the detection of circulating tumor cells (CTCs), cell-free DNA (cfDNA), and extracellular vesicles (EVs), whilehttps://test.maltsci.com/en/paper/pmid/36423290/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36423290/This study demonstrates that an mRNA-lipid nanoparticle vaccine effectively protects animals against 20 different lineages of the influenza virus, highlighting its potential as a versatile and robusthttps://test.maltsci.com/en/paper/pmid/36209106/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36209106/This review discusses the transformative impact of chimeric antigen receptor T (CAR-T) cell therapy on hematological malignancies, highlighting the development and success of various CAR-T products lihttps://test.maltsci.com/en/paper/pmid/35361951/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/35361951/This paper highlights the recent advancements in synthetic biology and soft-condensed matter, emphasizing their potential to create innovative biomaterials that can address significant challenges in hhttps://test.maltsci.com/en/paper/pmid/33784415/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33784415/The article discusses the updates to the AJCC TNM staging for cervical cancer as part of the forthcoming ninth edition of the staging manual, emphasizing significant changes such as the integration ofhttps://test.maltsci.com/en/paper/pmid/31363513/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31363513/The increasing complexity and volume of healthcare data are driving the adoption of artificial intelligence (AI) across various sectors, including diagnostics, patient engagement, and administrative fhttps://test.maltsci.com/en/paper/pmid/30617336/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30617336/This paper reviews the challenges of integrating AI technologies into clinical practice, addressing issues such as data privacy, algorithm transparency, and patient safety, while comparing the regulathttps://test.maltsci.com/en/paper/pmid/28187291/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28187291/This research highlights the potential of chimeric antigen receptor (CAR) T cells as a novel cancer treatment, while addressing the challenges in ensuring their reliability, safety, and efficacy againhttps://test.maltsci.com/en/paper/pmid/31815293/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31815293/This research highlights the historical neglect of peripheral T-cell lymphomas (PTCLs), which account for 6-10% of non-Hodgkin lymphoma cases and have seen minimal improvement in treatment outcomes cohttps://test.maltsci.com/en/paper/pmid/37375838/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/37375838/This article reviews the transformative potential of artificial intelligence (AI) in drug discovery, emphasizing its ability to enhance efficiency and accuracy while discussing the critical challengeshttps://test.maltsci.com/en/paper/pmid/33542518/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33542518/This review highlights the critical role of vaccines in combating antimicrobial resistance (AMR), a growing global threat due to the rise of drug-resistant pathogens that cause significant morbidity ahttps://test.maltsci.com/en/paper/pmid/31391919/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31391919/This review discusses recent advancements in single-cell sequencing technologies, emphasizing their ability to analyze genomes, transcriptomes, and multi-omics at the individual cell level, which revehttps://test.maltsci.com/en/paper/pmid/33149273/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33149273/This review explores the intricate roles of the alarmones ppGpp and pppGpp in the stringent response to nutrient stress, highlighting their involvement in various cellular processes such as DNA replichttps://test.maltsci.com/en/paper/pmid/24911500/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/24911500/This study introduces the Synthetic Biology Open Language (SBOL), a community-driven data standard designed to facilitate the exchange of synthetic biology designs among researchers, software tools, ahttps://test.maltsci.com/en/paper/pmid/18836471/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/18836471/This study investigates how the tumor microenvironment, characterized by chronic inflammation and the presence of regulatory T cells and myeloid suppressor cells, inhibits immune cell functions, therehttps://test.maltsci.com/en/paper/pmid/31350295/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31350295/This research highlights the role of both innate and adaptive immune cells in shaping the tumor microenvironment (TME), which influences cancer progression through interactions with cancer cells. By ehttps://test.maltsci.com/en/paper/pmid/32810447/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32810447/This research highlights that the tumor microenvironment is a dynamic and complex entity composed of various cells and extracellular components that actively promote cancer progression rather than merhttps://test.maltsci.com/en/paper/pmid/31341272/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31341272/In the wake of the Ebola virus disease epidemic in West Africa, this review highlights the urgent need for enhanced therapies against viral hemorrhagic fevers, focusing on promising compounds that dishttps://test.maltsci.com/en/paper/pmid/33811125/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33811125/This review discusses the emerging strategies for targeting the tumor microenvironment (TME) in cancer treatment, focusing on advanced therapies such as immunotherapies and antiangiogenic drugs that ahttps://test.maltsci.com/en/paper/pmid/33226648/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33226648/This study highlights the growing financial burden of cancer treatment on patients and families, emphasizing the lack of routine screening and management for financial hardship in clinical oncology prhttps://test.maltsci.com/en/paper/pmid/30501490/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/30501490/This international phase 2 pivotal study evaluated the efficacy of tisagenlecleucel, a CAR T-cell therapy targeting CD19, in adult patients with relapsed or refractory diffuse large B-cell lymphoma whhttps://test.maltsci.com/en/paper/pmid/29385370/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29385370/This global phase 2 study demonstrated that a single infusion of the anti-CD19 CAR T-cell therapy tisagenlecleucel achieved an 81% overall remission rate in pediatric and young adult patients with relhttps://test.maltsci.com/en/paper/pmid/21514248/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21514248/This study emphasizes the importance of the preclinical phase of Alzheimer''s disease (AD) as a critical window for therapeutic intervention, proposing a conceptual framework and operational criteria thttps://test.maltsci.com/en/paper/pmid/36670309/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/36670309/This research highlights the emerging role of organoid models in studying diabetes mellitus, emphasizing their ability to replicate human pancreatic cell development and the response of target organshttps://test.maltsci.com/en/paper/pmid/21436512/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/21436512/This paper introduces a novel approach called passive brain-computer interface (BCI), which integrates cognitive monitoring with real-time brain signal decoding to enhance user interaction by providinhttps://test.maltsci.com/en/paper/pmid/29170458/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29170458/This study explores the use of CRISPR/Cas9 for treating autosomal dominant genetic disorders, specifically through allele-specific gene disruption via non-homologous end-joining (NHEJ) in corneal epithttps://test.maltsci.com/en/paper/pmid/40252048/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/40252048/This review highlights the complexities of high-grade serous ovarian cancer (HGSOC), the most prevalent and aggressive subtype, which is often diagnosed at advanced stages due to asymptomatic early dihttps://test.maltsci.com/en/paper/pmid/32634611/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32634611/The KAMILLA study evaluates the efficacy of trastuzumab emtansine (T-DM1) in patients with HER2-positive breast cancer and brain metastases, revealing a best overall response rate of 21.4% and clinicahttps://test.maltsci.com/en/paper/pmid/32767764/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32767764/Bladder cancer, responsible for approximately 170,000 deaths annually, has historically been treated with platinum-based chemotherapy; however, recent advancements in genomic characterization have unvhttps://test.maltsci.com/en/paper/pmid/38598795/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/38598795/This multicenter randomized trial investigated the impact of early minimally invasive surgical evacuation of acute intracerebral hemorrhages compared to medical management, revealing that surgery signhttps://test.maltsci.com/en/paper/pmid/26845449/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26845449/This study highlights the critical role of the tumor microenvironment in influencing therapeutic responses and drug resistance, driven by factors such as soluble secretions and cell adhesion to stromahttps://test.maltsci.com/en/paper/pmid/33259885/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33259885/This paper reviews the critical role of the tumor microenvironment in cancer progression and treatment response, emphasizing its potential as a therapeutic target. It highlights recent advancements inhttps://test.maltsci.com/en/paper/pmid/32519436/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/32519436/This review explores the complex interactions within the tumor microenvironment, highlighting the roles of various stromal cells, including cancer-associated fibroblasts, immune cells, and endothelialhttps://test.maltsci.com/en/paper/pmid/26276713/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/26276713/This paper reviews the interactions between tumor cells and their microenvironment, highlighting how these dynamics can inform new therapeutic strategies alongside traditional treatments. By providinghttps://test.maltsci.com/en/paper/pmid/31906017/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31906017/This review highlights the significant role of the tumor microenvironment in cancer development and progression, emphasizing the interactions between malignant cells and various nonmalignant cells suchttps://test.maltsci.com/en/paper/pmid/29115304/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/29115304/This review highlights the increasing heterogeneity of cancer throughout its progression, which leads to diverse tumor cell populations with varying treatment sensitivities and contributes to therapeuhttps://test.maltsci.com/en/paper/pmid/23905721/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/23905721/This study explores the tuning of response rates in synthetic biology systems, emphasizing the importance of adjusting response curve shapes to optimize system dynamics and steady-state properties. Byhttps://test.maltsci.com/en/paper/pmid/34040228/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34040228/This review discusses the critical role of Type VII secretion systems (T7SSs) in both pathogenic and non-pathogenic mycobacteria, particularly focusing on their function in Mycobacterium tuberculosis,https://test.maltsci.com/en/paper/pmid/41713417/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/41713417/PocketXMol is an innovative atom-level model designed for generative tasks related to protein pocket interactions, enabling structure prediction and small molecule and peptide design without the needhttps://test.maltsci.com/en/paper/pmid/28835719/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/28835719/This opinion article highlights the pivotal role of single cells in cancer biology, emphasizing that single-cell sequencing technologies have overcome historical limitations in cancer research. The auhttps://test.maltsci.com/en/paper/pmid/34412644/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/34412644/This study explores the potential of single-cell sequencing of circulating tumor cells (CTCs) to overcome tumor heterogeneity and elucidate the genomic characteristics of low-abundance tumor stem cellhttps://test.maltsci.com/en/paper/pmid/9468467/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/9468467/This study evaluates the diagnostic value of the APOE epsilon4 allele in Alzheimer''s disease by comparing clinical diagnoses with autopsy-confirmed cases in 2,188 patients. While the APOE genotype alohttps://test.maltsci.com/en/paper/pmid/33480945/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/33480945/This paper highlights the limitations of current human organoid models, particularly their lack of functional vasculature, which hinders structural maturity and leads to necrosis in core regions due thttps://test.maltsci.com/en/paper/pmid/31959346/Mon, 01 Jan 0001 00:00:00 +0000https://test.maltsci.com/en/paper/pmid/31959346/The AcSé vemurafenib trial evaluated the efficacy of vemurafenib in treating non-small-cell lung cancer (NSCLC) patients with BRAF mutations, revealing that while 44.9% of patients with the BRAFV600 m